Q4G1G8.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
31,482 Da
NCBI Official Full Name
Cholesterol 25-hydroxylase
NCBI Protein Information
cholesterol 25-hydroxylase; Cholesterol 25-monooxygenase
UniProt Protein Name
Cholesterol 25-hydroxylase
UniProt Synonym Protein Names
Cholesterol 25-monooxygenase
UniProt Entry Name
CH25H_PIG
UniProt Comments for CH25H
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
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Pathways associated with CH25H recombinant protein
Organs/Tissues associated with CH25H recombinant protein
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