C,HBcAg recombinant protein :: Capsid Recombinant Protein

Catalog #	MBS1093382
Unit / Price	0.01 mg (Yeast) / $260 +1 FREE 8GB USB 0.05 mg (Yeast) / $360 +1 FREE 8GB USB 0.1 mg (Yeast) / $595 +1 FREE 8GB USB 0.2 mg (Yeast) / $965 +1 FREE 8GB USB 0.5 mg (Yeast) / $1,345 +1 FREE 8GB USB 1 mg (Yeast) / $2,065 +2 FREE 8GB USB

Product Name

Capsid (C,HBcAg), Recombinant Protein

Recombinant Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C) Capsid protein

Product Synonym Names

Core antigen; Core protein; HBcAgp21.5

Product Gene Name

C,HBcAg recombinant protein

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Research Use Only

For Research Use Only. Not for use in diagnostic procedures.

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Sequence Positions

1-183aa; Full length

Sequence

MDIDPYKEFG ASVEVLSFLP SDFFPSNRDL LDTASALDRE ALESPEHCSP HHTALRQAIL CWGELMNLAT WVGSNLEDPA SRELVVSYVN VNMGLKIRQL LWFHISCLTF GRETVLEYLV SFGVWIRTPP AYRPPNAPIL STLPETTVVR RRGRSPRRRT PSPRRRRSQS PRRRRSQSRE SQC

3D Structure

ModBase 3D Structure for P0C6H7

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Purity/Purification

Greater than 90% as determined by SDS-PAGE. (lot specific)

Form/Format

Liquid containing glycerol

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Other Notes

Small volumes of C,HBcAg recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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Related Product Information for
C,HBcAg recombinant protein

Self assbles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions. Encapsidates hepatitis delta genome.

SDS-Page of C,HBcAg recombinant protein

C,HBcAg recombinant protein SDS-Page image

(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)

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NCBI/Uniprot data below describe general gene information for C,HBcAg. It may not necessarily be applicable to this product.

NCBI GI #

170652933

NCBI Accession #

P0C6H7.1 [Other Products]

UniProt Primary Accession #

P0C6H7 [Other Products]

Molecular Weight

23kD

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NCBI Official Full Name

Capsid protein

UniProt Protein Name

Capsid protein

UniProt Synonym Protein Names

Core antigen; Core protein; HBcAg; p21.5

Protein Family

Capsid protein

UniProt Gene Name

C [Similar Products]

UniProt Entry Name

CAPSD_HBVC7

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UniProt Comments for C,HBcAg

Self assembles to form an icosahedral capsid. Most capsid appear to be large particles with a icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins. Entering capsid are transported along microtubules to the nucleus. Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta. Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153. Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm. Immature capsids get stucked in the basket. Capsids encapsulate the pre-genomic RNA and the P protein. Pre-genomic RNA is reverse transcribed into DNA while the capsid is still in the cytoplasm. The capsid can then either be directed to the nucleus, providing more genome for transcription, or bud through the endoplasmic reticulum to provide new virions ().

Product References and Citations for C,HBcAg recombinant protein

The dominant hepatitis B virus genotype identified in Tibet is a C/D hybrid.Cui C., Shi J., Hui L., Xi H., Zhuoma X., Quni X., Tsedan X., Hu G.J. Gen. Virol. 83:2773-2777(2002)

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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.