NP_997698.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
269,988 Da
NCBI Official Full Name
ATP-binding cassette sub-family A member 2 isoform b
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family A (ABC1), member 2
NCBI Official Synonym Symbols
NCBI Protein Information
ATP-binding cassette sub-family A member 2; ATP-binding cassette 2; ATP-binding cassette transporter 2; ATP-binding cassette, sub-family A, member 2
UniProt Protein Name
ATP-binding cassette sub-family A member 2
UniProt Synonym Protein Names
ATP-binding cassette transporter 2; ATP-binding cassette 2
UniProt Synonym Gene Names
UniProt Entry Name
ABCA2_HUMAN
NCBI Summary for ABCA2
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA2
ABCA2: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ABC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: membrane; lysosome; lysosomal membrane; cytoplasmic membrane-bound vesicle; integral to membrane; microtubule organizing center; endosome membrane; ATP-binding cassette (ABC) transporter complex; endosome
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATPase activity; nucleotide binding; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; response to drug; cholesterol homeostasis; transport; response to steroid hormone stimulus; lipid metabolic process; transmembrane transport; regulation of intracellular cholesterol transport
Research Articles on ABCA2
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Products associated with ABCA2 elisa kit
Pathways associated with ABCA2 elisa kit
Diseases associated with ABCA2 elisa kit
Organs/Tissues associated with ABCA2 elisa kit
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