NP_002079.3
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
glutamate receptor ionotropic, kainate 5 isoform 2
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, kainate 5
NCBI Protein Information
glutamate receptor ionotropic, kainate 5; glutamate receptor KA2; excitatory amino acid receptor 2
UniProt Protein Name
Glutamate receptor ionotropic, kainate 5
UniProt Synonym Protein Names
Excitatory amino acid receptor 2; EAA2; Glutamate receptor KA-2; KA2
UniProt Synonym Gene Names
UniProt Entry Name
GRIK5_HUMAN
NCBI Summary for GRIK5
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for GRIK5
GluR KA2: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; endoplasmic reticulum; postsynaptic density; dendrite; plasma membrane; terminal button; perikaryon; cell junction
Molecular Function: identical protein binding; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; SH3 domain binding; PDZ domain binding
Biological Process: synaptic transmission, glutamatergic; synaptic transmission; ionotropic glutamate receptor signaling pathway; regulation of synaptic vesicle fusion to presynaptic membrane; positive regulation of neuron apoptosis; regulation of excitatory postsynaptic membrane potential; receptor clustering; protein retention in ER; establishment of cellular localization
Research Articles on GRIK5
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with GRIK5 elisa kit
Pathways associated with GRIK5 elisa kit
Diseases associated with GRIK5 elisa kit
Organs/Tissues associated with GRIK5 elisa kit
|