NP_000844.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,517 Da
NCBI Official Full Name
glutathione S-transferase theta-1 isoform a
NCBI Official Synonym Full Names
glutathione S-transferase theta 1
NCBI Protein Information
glutathione S-transferase theta-1; GST class-theta-1; glutathione transferase T1-1
UniProt Protein Name
Glutathione S-transferase theta-1
UniProt Synonym Protein Names
GST class-theta-1; Glutathione transferase T1-1
UniProt Entry Name
GSTT1_HUMAN
NCBI Summary for GSTtheta1/GSTt1
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. GSTT1 and GSTT2 share 55% amino acid sequence identity and both may play an important role in human carcinogenesis. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. This GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes, which are also located on chromosome 22, have been identified. [provided by RefSeq, Jun 2014]
UniProt Comments for GSTtheta1/GSTt1
GSTT1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. Belongs to the GST superfamily. Theta family.
Protein type: EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: cytosol
Molecular Function: glutathione transferase activity; glutathione peroxidase activity
Biological Process: glutathione metabolic process; xenobiotic metabolic process
Research Articles on GSTtheta1/GSTt1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with GSTtheta1/GSTt1 elisa kit
Pathways associated with GSTtheta1/GSTt1 elisa kit
Diseases associated with GSTtheta1/GSTt1 elisa kit
Organs/Tissues associated with GSTtheta1/GSTt1 elisa kit
|