NP_001273332.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,661 Da
NCBI Official Full Name
MHC class II transactivator isoform 3
NCBI Official Synonym Full Names
class II, major histocompatibility complex, transactivator
NCBI Protein Information
MHC class II transactivator; NLR family, acid domain containing; MHC class II transactivator type III; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
UniProt Protein Name
MHC class II transactivator
UniProt Synonym Gene Names
UniProt Entry Name
C2TA_HUMAN
NCBI Summary for MHC III / HLA-III
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Comments for MHC III / HLA-III
CIITA: a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production.
Protein type: EC 2.7.11.1; DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16p13
Cellular Component: nucleoplasm; PML body
Molecular Function: protein C-terminus binding; protein binding; GTP binding; DNA binding; transcription activator binding; transcription coactivator activity; protein complex binding; transferase activity, transferring acyl groups; kinase activity; ATP binding
Biological Process: response to antibiotic; transcription, DNA-dependent; negative regulation of collagen biosynthetic process; positive regulation of MHC class II biosynthetic process; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of MHC class I biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; immune response; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphorylation
Disease: Rheumatoid Arthritis; Bare Lymphocyte Syndrome, Type Ii
Research Articles on MHC III / HLA-III
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Products associated with MHC III / HLA-III elisa kit
Pathways associated with MHC III / HLA-III elisa kit
Diseases associated with MHC III / HLA-III elisa kit
Organs/Tissues associated with MHC III / HLA-III elisa kit
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