NP_055847.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,281 Da
NCBI Official Full Name
sister chromatid cohesion protein PDS5 homolog B
NCBI Official Synonym Full Names
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
NCBI Protein Information
sister chromatid cohesion protein PDS5 homolog B; androgen-induced shutoff 3; androgen-induced proliferation inhibitor; androgen induced inhibitor of proliferation; androgen-induced prostate proliferative shutoff-associated protein AS3
UniProt Protein Name
Sister chromatid cohesion protein PDS5 homolog B
UniProt Synonym Protein Names
Androgen-induced proliferation inhibitor; Androgen-induced prostate proliferative shutoff-associated protein AS3
UniProt Synonym Gene Names
UniProt Entry Name
PDS5B_HUMAN
NCBI Summary for PDS5B
This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, May 2010]
UniProt Comments for PDS5B
APRIN: a widely expressed nuclear protein. Is lost in many cancers and may function as a tumor suppressor. Correlates with differentiation in embryonal carcinoma stem cells; its knockdown disrupted Nanog, Oct4, and SOX2 regulation. Plays a role in androgen-induced proliferative arrest in prostate cells. Is upregulated in androgen-sensitive LNCaP prostate cancer cells undergoing androgen-induced proliferative block. Required for maintenance of sister chromatid cohesion during mitosis. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Belongs to the PDS5 family. Induced by the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Phosphorylated upon DNA damage. Maximum levels occur 18-20 hours after androgen exposure. Interacts with the cohesin complex. Phosphorylated upon DNA damage, probably by ATM or ATR. Five isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Cell development/differentiation
Chromosomal Location of Human Ortholog: 13q12.3
Cellular Component: nucleoplasm; chromosome; nucleus; cytosol; chromatin; chromosome, pericentric region
Molecular Function: protein binding; DNA binding; ATP binding
Biological Process: cell proliferation; negative regulation of cell proliferation; cell division; mitotic sister chromatid cohesion; mitotic cell cycle; regulation of cell proliferation
Research Articles on PDS5B
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Products associated with PDS5B elisa kit
Pathways associated with PDS5B elisa kit
Diseases associated with PDS5B elisa kit
Organs/Tissues associated with PDS5B elisa kit
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