NP_001813
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
N-chimaerin isoform 1
NCBI Official Synonym Full Names
chimerin 1
NCBI Official Synonym Symbols
NC; CHN; DURS2; ARHGAP2; RHOGAP2 [Similar Products]
NCBI Protein Information
N-chimaerin
UniProt Protein Name
N-chimaerin
UniProt Synonym Protein Names
A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2
UniProt Synonym Gene Names
UniProt Entry Name
CHIN_HUMAN
NCBI Summary for CHN1
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
UniProt Comments for CHN1
ARHGAP2: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. In neurons in brain regions that are involved in learning and memory processes. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, Rac/Rho; Adaptor/scaffold; GAPs
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: cytoplasm; cytosol
Molecular Function: ephrin receptor binding; GTPase activator activity; metal ion binding; protein binding; SH3/SH2 adaptor activity
Biological Process: ephrin receptor signaling pathway; motor axon guidance; positive regulation of GTPase activity; positive regulation of signal transduction; regulation of axonogenesis; regulation of GTPase activity; regulation of small GTPase mediated signal transduction
Disease: Duane Retraction Syndrome 2
Research Articles on CHN1
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Products associated with CHN1 blocking peptide
Pathways associated with CHN1 blocking peptide
Diseases associated with CHN1 blocking peptide
Organs/Tissues associated with CHN1 blocking peptide
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