P36544.5
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
Neuronal acetylcholine receptor subunit alpha-7
NCBI Official Synonym Full Names
CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion
NCBI Official Synonym Symbols
D-10; CHRNA7; NACHRA7; CHRNA7-DR1 [Similar Products]
NCBI Protein Information
CHRNA7-FAM7A fusion protein
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-7
UniProt Synonym Gene Names
UniProt Entry Name
ACHA7_HUMAN
NCBI Summary for CHRFAM7A
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]
UniProt Comments for CHRFAM7A
nAChRA7: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 7/CHRNA7 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, cation; Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; plasma membrane; integral to membrane; cell junction
Molecular Function: toxin binding; chloride channel regulator activity; protein homodimerization activity; beta-amyloid binding; acetylcholine-gated cation channel activity; acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding
Biological Process: response to nicotine; cellular calcium ion homeostasis; synaptic transmission; positive regulation of angiogenesis; activation of MAPK activity; calcium ion transport; positive regulation of cell proliferation; response to hypoxia; ion transport; negative regulation of tumor necrosis factor production; signal transduction; cognition; memory
Disease: Chromosome 15q13.3 Deletion Syndrome
Research Articles on CHRFAM7A
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Products associated with anti-CHRFAM7A antibody
Pathways associated with anti-CHRFAM7A antibody
Diseases associated with anti-CHRFAM7A antibody
Organs/Tissues associated with anti-CHRFAM7A antibody
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