NP_001186208.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,898 Da
NCBI Official Full Name
neuronal acetylcholine receptor subunit alpha-6 isoform 2
NCBI Official Synonym Full Names
cholinergic receptor, nicotinic, alpha 6 (neuronal)
NCBI Official Synonym Symbols
NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-6; cholinergic receptor, nicotinic, alpha polypeptide 6; acetylcholine receptor, nicotinic, alpha 6 (neuronal)
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-6
UniProt Entry Name
ACHA6_HUMAN
NCBI Summary for CHRNA6
This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]
UniProt Comments for CHRNA6
nAChRA6: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 6/CHRNA6 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8p11.21
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; plasma membrane; cell junction
Molecular Function: acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity
Biological Process: synaptic transmission; membrane depolarization; transport; signal transduction; regulation of dopamine secretion
Research Articles on CHRNA6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with CHRNA6 elisa kit
Diseases associated with CHRNA6 elisa kit
Organs/Tissues associated with CHRNA6 elisa kit
|