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CIB1 recombinant protein

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Catalog # MBS203133
Unit / Price
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  0.1 mg  /  $310 +1 FREE 8GB USB
  0.5 mg  /  $720 +1 FREE 8GB USB
Product Name

CIB1, Recombinant Protein

Popular Item
Full Product Name

CIB1, 1-191aa, Human, His tag, E Coli

Product Synonym Names
Calcium and integrin binding 1; CIB; KIP (Kinase interacting protein); SIP2-28 (SNK interacting protein2-28); CALMYRIN; CIB1; Calcium and integrin binding 1 Calcium and integrin binding 1 (calmyrin); Calcium and integrin binding protein 1; CIB; DNA PKcs interacting protein; Human Snk interacting protein 2 to 28 mRNA complete cds; Kinase interacting protein; PRKDCIP; SIP2 28; SNK interacting protein 2 to 28.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
U82226 mRNA
3D Structure
ModBase 3D Structure for Q99828
E Coli
> 95% by SDS-PAGE
Liquid in 20mM Tris pH 8.0, 5mM DTT
1 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Tag Information
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of CIB1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CIB1 recombinant protein
CIB, KIP (Kinase interacting protein), SIP2-28 (SNK interacting protein2-28), CALMYRIN Description: CIB1 (Calcium and integrin binding 1) is regulatory protein with 50% homology to calmodulin and calcineurin B, that encodes a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. Also CIB1 is widely expressed and binds to a number of effectors, such as integrin alpha IIb, PAK1, and polo-like kinases, in different tissues. Recombinant human CIB1, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
Product Categories/Family for CIB1 recombinant protein
Applications Tested/Suitable for CIB1 recombinant protein

NCBI/Uniprot data below describe general gene information for CIB1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23kDa (211aa), confirmed by MALDI-TOF.
NCBI Official Full Name
calcium and integrin-binding protein 1 isoform b
NCBI Official Synonym Full Names
calcium and integrin binding 1
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
calcium and integrin-binding protein 1
UniProt Protein Name
Calcium and integrin-binding protein 1
UniProt Synonym Protein Names
Calcium- and integrin-binding protein; CIBP; Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; KIP; SNK-interacting protein 2-28; SIP2-28
UniProt Gene Name
UniProt Synonym Gene Names
CIB; KIP; PRKDCIP; CIB; CIBP; KIP; SIP2-28  [Similar Products]
NCBI Summary for CIB1
This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
UniProt Comments for CIB1
Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.Isoform 2: Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion.
Product References and Citations for CIB1 recombinant protein
Yuan W, et al, (2006). Mol Cell Biochem. 26 (22): 8507; Yuan, et al, (2006). J Cell Biol. 172 (2) :169-75

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