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CIDEA cdna clone

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Catalog # MBS1269931
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
CIDEA cdna clone
Product Name

CIDEA, cDNA Clone

Popular Item
Full Product Name

CIDEA cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgcgagggg accgggcttc tgggggtcct ggaaatcaca acgggagctg ggcgcgggag gggcccaggc ttggcccctc ctggaagcgc gggctctggt ctccgagggg aggccccaac cgtccggcgg agccctccag gcccctgaca tttatgggat cacagactaa gcgagtcctg ttcaccccgc tcatgcatcc agctcgccct ttccgggtct ccaaccatga caggagcagc cggcgtgggg tgatggcaag cagcctgcag gagctcatca gcaagactct ggatgccctc gtcatcgcta ccggactggt cactctggtg ctggaggaag atggcaccgt ggtggacaca gaagagttct ttcagacctt gggagacaac acgcatttca tgatcttgga aaaaggacag aagtggatgc cgggcagcca gcacgtcccc acttgctcgc cgccgaagag gtcgggaata gcgagagtca ccttcgactt gtacaggctg aaccccaagg acttcatcgg ctgccttaac gtgaaggcca ccatgtatga gatgtactcc gtgtcctacg acatccggtg cacgggactc aagggcctgc tgaggagtct gctgcggttc ctgtcctact ccgcccaggt gacgggacag tttctcatct atctgggcac atacatgctc cgggtgctgg atgacaagga agagcggcca tccctccggt cacaagccaa gggcaggttc acgtgtggat ag
OMIM
604440
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CIDEA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CIDEA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,687 Da
NCBI Official Full Name
Homo sapiens cell death-inducing DFFA-like effector a, mRNA
NCBI Official Synonym Full Names
cell death-inducing DFFA-like effector a
NCBI Official Symbol
CIDEA  [Similar Products]
NCBI Official Synonym Symbols
CIDE-A
  [Similar Products]
NCBI Protein Information
cell death activator CIDE-A
UniProt Protein Name
Cell death activator CIDE-A
UniProt Synonym Protein Names
Cell death-inducing DFFA-like effector A
Protein Family
UniProt Gene Name
CIDEA  [Similar Products]
UniProt Entry Name
CIDEA_HUMAN
NCBI Summary for CIDEA
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]
UniProt Comments for CIDEA
CIDEA: Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin- resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle.

Protein type: Apoptosis; Mitochondrial

Chromosomal Location of Human Ortholog: 18p11.21|18

Cellular Component: cytoplasm; lipid particle; mitochondrial envelope; mitochondrion; nucleus

Molecular Function: protein homodimerization activity

Biological Process: cell death; lipid metabolic process; negative regulation of cytokine secretion; negative regulation of lipid catabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tumor necrosis factor production; regulation of apoptosis; sequestering of lipid; thermoregulation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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