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CISH recombinant protein :: Cytokine-inducible SH2-containing protein (CISH) Recombinant Protein

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Catalog # MBS1384089
Unit / Price
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  0.05 mg (E-Coli)  /  $650 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $770 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $875 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $965 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,000 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,040 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,240 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,445 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,445 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,875 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,890 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,025 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,935 +3 FREE 8GB USB
CISH recombinant protein
Product Name

Cytokine-inducible SH2-containing protein (CISH), Recombinant Protein

Full Product Name

Recombinant Chicken Cytokine-inducible SH2-containing protein (CISH)

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-249aa, full length protein
Sequence
MILCVPGPHP LLAEEKIQRL SLRGIAEDLT EHIMQPLPVP AFPEEPAPTF AAPEPDGSAP QTRDPEEDLL CIAKTFSYLR ESGWYWGSIT ASEAKQHLQK MPEGTFLVRD STHPSYLFTL SVKTNRGPTN VRIEYADSKF RLDSNYLSKP RILAFPDVVS LIQHYVTSCT TESKSEAPYP PPAPLPPVQK EVAVAAVHLK LLRPLGRRDS IPSLQHLCRL RINRCTTEVE RLPLPRRMGD YLKQYPFQL
3D Structure
ModBase 3D Structure for Q9PW70
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Chicken
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CISH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CISH recombinant protein
This protein contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for CISH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
28,118 Da
NCBI Official Full Name
cytokine-inducible SH2-containing protein
NCBI Official Synonym Full Names
cytokine inducible SH2 containing protein
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
cytokine-inducible SH2-containing protein
UniProt Protein Name
Cytokine-inducible SH2-containing protein
UniProt Synonym Protein Names
CIS-1; Suppressor of cytokine signaling; SOCS
UniProt Gene Name
UniProt Synonym Gene Names
CIS; CIS; SOCS  [Similar Products]
UniProt Comments for CISH
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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