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CKM protein :: Creatine Kinase MM Protein

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Catalog # MBS173061
Unit / Price
  100 Units  /  $205 +1 FREE 8GB USB
  1000 Units  /  $440 +1 FREE 8GB USB
  5000 Units  /  $1,605 +2 FREE 8GB USB
CKM protein
Product Name

Creatine Kinase MM (CKM), Protein

Also Known As

Creatine Kinase MM (CK-MM), Human Skeletal Muscle

Product Synonym Names
CK-MM; CKMM; Creatine Kinase MM (CK-MM), Human Skeletal Muscle - 50% Glycerol
Product Gene Name
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
381
OMIM
123310
3D Structure
ModBase 3D Structure for P06732
Purity/Purification
>= 96% (SDS-PAGE)
Form/Format
50% Glycerol
Appearance: Light to dark amber liquid
Source
Human Skeletal Muscle
EC Number
2.7.3.2
Unit Definition
One unit will catalyze the transphosphorylation of one micromole of phosphate from creatine phosphate to ADP per minute at 37 degree C.
Specific Activity
>= 500 U/mg protein
Recertification
2 years
Protein
>= 5.0 mg/mL (Coomassie)
Isozyme Content
CK-MM: >= 99%, CK-BB: < 1%, CK-MB: < 1% (Helena QuickGel CK)
Contaminants
GOT/AST: <=0.01%, LDH: <=0.01% (Dimension Clinical Chemistry System)
CAS Number
9001-15-4
Activity
>= 1,000 U/mL (Dimension Clinical Chemistry System)
Preparation and Storage
At -20 degree C
Other Notes
Small volumes of CKM protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CKM protein
MyBioSource is the leading manufacturer of human muscle Creatine Kinase MM (CKMM,CK-MM) for medical research and diagnostic manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available.

Human CKMM isoenzyme, also known as human CPK-3 isoenzyme, is normally responsible for almost all human CPK enzyme activity in healthy individuals. When human CK-MM isoenzyme is elevated, this usually indicates injury or stress to skeletal muscle.
NCBI/Uniprot data below describe general gene information for CKM. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,101 Da
NCBI Official Full Name
creatine kinase M-type
NCBI Official Synonym Full Names
creatine kinase, muscle
NCBI Official Symbol
NCBI Official Synonym Symbols
CKMM; M-CK
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NCBI Protein Information
creatine kinase M-type; creatine kinase M chain
UniProt Protein Name
Creatine kinase M-type
UniProt Synonym Protein Names
Creatine kinase M chain; M-CKCreatine kinase M-type, N-terminally processed
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
KCRM_HUMAN
NCBI Summary for CKM
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
UniProt Comments for CKM
CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family.

Protein type: EC 2.7.3.2; Kinase, other; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytosol

Molecular Function: creatine kinase activity; ATP binding

Biological Process: phosphocreatine biosynthetic process; phosphorylation; creatine metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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