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CLC1 elisa kit :: Cat Chloride Channel Protein 1 ELISA Kit

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Catalog # MBS051940
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CLC1 elisa kit
Product Name

Chloride Channel Protein 1 (CLC1), ELISA Kit

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Full Product Name

Cat Chloride Channel Protein 1 ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Chromosome Location
Chromosome: 7; NC_000007.13 (143013219..143049097). Location: 7q35
OMIM
118425
3D Structure
ModBase 3D Structure for P35523
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of CLC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forCLC1purchase
MBS051940 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Chloride Channel Protein 1 (CLC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CLC1. The ELISA analytical biochemical technique of the MBS051940 kit is based on CLC1 antibody-CLC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CLC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CLC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for CLC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
108,626 Da
NCBI Official Full Name
chloride channel protein 1
NCBI Official Synonym Full Names
chloride channel, voltage-sensitive 1
NCBI Official Symbol
CLCN1  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
chloride channel protein 1; clC-1; chloride channel 1, skeletal muscle; chloride channel protein, skeletal muscle
UniProt Protein Name
Chloride channel protein 1
UniProt Synonym Protein Names
Chloride channel protein, skeletal muscle
Protein Family
UniProt Gene Name
CLCN1  [Similar Products]
UniProt Synonym Gene Names
CLC1; ClC-1  [Similar Products]
UniProt Entry Name
CLCN1_HUMAN
NCBI Summary for CLC1
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
UniProt Comments for CLC1
CLCN1: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. Defects in CLCN1 are the cause of Thomsen disease (THD); also known as autosomal dominant myotonia congenita (MCD). THD is characterized by skeletal muscle stiffness (delayed relaxation), due to membrane hyperexcitability. A variant form of Thomsen disease is myotonia levior that is characterized by milder symptoms, later onset and absence of muscle hypo- and hypertrophy. Defects in CLCN1 are the cause of autosomal recessive myotonia congenita (MCR); also known as Becker disease. Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.

Protein type: Membrane protein, integral; Transporter, ion channel; Transporter; Membrane protein, multi-pass; Channel, chloride

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: integral to plasma membrane; plasma membrane; sarcolemma

Molecular Function: chloride channel activity; voltage-gated chloride channel activity

Biological Process: muscle contraction; transport; action potential propagation; transmembrane transport

Disease: Myotonia Congenita, Autosomal Recessive; Myotonia Congenita, Autosomal Dominant
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with CLC1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >113 publications with CLC1 and Muscle
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