NP_001297.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
23,319 Da
NCBI Official Full Name
claudin-3
NCBI Official Synonym Full Names
claudin 3
NCBI Official Synonym Symbols
RVP1; HRVP1; C7orf1; CPE-R2; CPETR2 [Similar Products]
NCBI Protein Information
claudin-3
UniProt Protein Name
Claudin-3
UniProt Synonym Protein Names
Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; Rat ventral prostate.1 protein homolog; hRVP1
UniProt Synonym Gene Names
UniProt Entry Name
CLD3_HUMAN
NCBI Summary for Cldn3
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
UniProt Comments for Cldn3
Claudin-3: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cytoskeletal
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: apicolateral plasma membrane; integral to membrane; integral to plasma membrane; lateral plasma membrane; tight junction
Molecular Function: identical protein binding; structural molecule activity; transmembrane receptor activity
Biological Process: calcium-independent cell-cell adhesion; protein heterooligomerization; protein homooligomerization; response to hypoxia; signal transduction
Research Articles on Cldn3
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Pathways associated with Cldn3 elisa kit
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Organs/Tissues associated with Cldn3 elisa kit
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