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CLEC7A cdna clone

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Catalog # MBS1271498
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
CLEC7A cdna clone
Product Name

CLEC7A, cDNA Clone

Popular Item
Full Product Name

CLEC7A cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggaatatc atcctgattt agaaaatttg gatgaagatg gatatactca attacacttc gactctcaaa gcaataccag gatagctgtt gtttcagaga aaggatcgtg tgctgcatct cctccttggc gcctcattgc tgtaattttg ggaatcctat gcttggtaat actggtgata gctgtggtcc tgggtaccat ggctggtttc aaagctgtgg aattcaaagg ataa
OMIM
606264
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of CLEC7A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CLEC7A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13,138 Da
NCBI Official Full Name
Homo sapiens C-type lectin domain family 7, member A, mRNA
NCBI Official Synonym Full Names
C-type lectin domain family 7 member A
NCBI Official Symbol
CLEC7A  [Similar Products]
NCBI Official Synonym Symbols
BGR; CD369; CANDF4; SCARE2; DECTIN1; CLECSF12
  [Similar Products]
NCBI Protein Information
C-type lectin domain family 7 member A
UniProt Protein Name
C-type lectin domain family 7 member A
UniProt Synonym Protein Names
Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1
UniProt Gene Name
CLEC7A  [Similar Products]
UniProt Synonym Gene Names
BGR; CLECSF12; DECTIN1; DC-associated C-type lectin 1; Dectin-1  [Similar Products]
UniProt Entry Name
CLC7A_HUMAN
NCBI Summary for CLEC7A
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
UniProt Comments for CLEC7A
dectin-1: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2

Cellular Component: integral to membrane; intracellular membrane-bound organelle; nucleoplasm; plasma membrane

Molecular Function: carbohydrate binding; pattern recognition receptor activity; protein binding

Biological Process: carbohydrate mediated signaling; cell recognition; phagocytosis, recognition; stimulatory C-type lectin receptor signaling pathway; T cell activation

Disease: Aspergillosis, Susceptibility To; Candidiasis, Familial, 4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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