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CNGA3 cdna clone

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Catalog # MBS1270879
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $390 +1 FREE 8GB USB
CNGA3 cdna clone
Product Name

CNGA3, cDNA Clone

Also Known As

CNGA3 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
2085
Sequence
ATGGCCAAGA TCAACACCCA ATACTCCCAC CCCTCCAGGA CCCACCTCAA GGTAAAGACC TCAGACCGAG ATCTCAATCG CGCTGAAAAT GGCCTCAGCA GAGCCCACTC GTCAAGTGAG GAGACATCGT CAGTGCTGCA GCCGGGGATC GCCATGGAGA CCAGAGGACT GGCTGACTCC GGGCAGGGCT CCTTCACCGG CCAGGGGATC GCCAGGCTGT CGCGCCTCAT CTTCTTGCTG CGCAGGTGGG CTGCCAGGCA TGTGCACCAC CAGGACCAGG GACCGGACTC TTTTCCTGAT CGTTTCCGTG GAGCCGAGCT TAAGGAGGTG TCCAGCCAAG AAAGCAATGC CCAGGCAAAT GTGGGCAGCC AGGAGCCAGC AGACAGAGGG AGAAGCGCCT GGCCCCTGGC CAAATGCAAC ACTAACACCA GCAACAACAC GGAGGAGGAG AAGAAGACGA AAAAGAAGGA TGCGATCGTG GTGGACCCGT CCAGCAACCT GTACTACCGC TGGCTGACCG CCATCGCCCT GCCTGTCTTC TATAACTGGT ATCTGCTTAT TTGCAGGGCC TGTTTCGATG AGCTGCAGTC CGAGTACCTG ATGCTGTGGC TGGTCCTGGA CTACTCGGCA GATGTCCTGT ATGTCTTGGA TGTGCTTGTA CGAGCTCGGA CAGGTTTTCT CGAGCAAGGC TTAATGGTCA GTGATACCAA CAGGCTGTGG CAGCATTACA AGACGACCAC GCAGTTCAAG CTGGATGTGT TGTCCCTGGT CCCCACCGAC CTGGCTTACT TAAAGGTGGG CACAAACTAC CCAGAAGTGA GGTTCAACCG CCTACTGAAG TTTTCCCGGC TCTTTGAATT CTTTGACCGC ACAGAGACAA GGACCAACTA CCCCAATATG TTCAGGATTG GGAACTTGGT CTTGTACATT CTCATCATCA TCCACTGGAA TGCCTGCATC TACTTTGCCA TTTCCAAGTT CATTGGTTTT GGGACAGACT CCTGGGTCTA CCCAAACATC TCAATCCCAG AGCATGGGCG CCTCTCCAGG AAGTACATTT ACAGTCTCTA CTGGTCCACC TTGACCCTTA CCACCATTGG TGAGACCCCA CCCCCCGTGA AAGATGAGGA GTATCTCTTT GTGGTCGTAG ACTTCTTGGT GGGTGTTCTG ATTTTTGCCA CCATTGTGGG CAATGTGGGC TCCATGATCT CGAATATGAA TGCCTCACGG GCAGAGTTCC AGGCCAAGAT TGATTCCATC AAGCAGTACA TGCAGTTCCG CAAGGTCACC AAGGACTTGG AGACGCGGGT TATCCGGTGG TTTGACTACC TGTGGGCCAA CAAGAAGACG GTGGATGAGA AGGAGGTGCT CAAGAGCCTC CCAGACAAGC TGAAGGCTGA GATCGCCATC AACGTGCACC TGGACACGCT GAAGAAGGTT CGCATCTTCC AGGACTGTGA GGCAGGGCTG CTGGTGGAGC TGGTGCTGAA GCTGCGACCC ACTGTGTTCA GCCCTGGGGA TTATATCTGC AAGAAGGGAG ATATTGGGAA GGAGATGTAC ATCATCAACG AGGGCAAGCT GGCCGTGGTG GCTGATGATG GGGTCACCCA GTTCGTGGTC CTCAGCGATG GCAGCTACTT CGGGGAGATC AGCATTCTGA ACATCAAGGG GAGCAAGTCG GGGAACCGCA GGACGGCCAA CATCCGCAGC ATTGGCTACT CAGACCTGTT CTGCCTCTCA AAGGACGATC TCATGGAGGC CCTCACCGAG TACCCCGAAG CCAAGAAGGC CCTGGAGGAG AAAGGACGGC AGATCCTGAT GAAAGACAAC CTGATCGATG AGGAGCTGGC CAGGGCGGGC GCGGACCCCA AGGACCTTGA GGAGAAAGTG GAGCAGCTGG GGTCCTCCCT GGACACCCTG CAGACCAGGT TTGCACGCCT CCTGGCTGAG TACAACGCCA CCCAGATGAA GATGAAGCAG CGTCTCAGCC AACTGGAAAG CCAGGTGAAG GGTGGTGGGG ACAAGCCCCT GGCTGATGGG GAAGTTCCCG GGGATGCTAC AAAAACAGAG GACAAACAAC AGTGA
OMIM
216900
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of CNGA3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CNGA3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,062 Da
NCBI Official Full Name
Homo sapiens cyclic nucleotide gated channel alpha 3, mRNA
NCBI Official Synonym Full Names
cyclic nucleotide gated channel alpha 3
NCBI Official Symbol
CNGA3  [Similar Products]
NCBI Official Synonym Symbols
CNG3; ACHM2; CCNC1; CCNCa; CNCG3; CCNCalpha
  [Similar Products]
NCBI Protein Information
cyclic nucleotide-gated cation channel alpha-3
UniProt Protein Name
Cyclic nucleotide-gated cation channel alpha-3
UniProt Synonym Protein Names
Cone photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3
UniProt Gene Name
CNGA3  [Similar Products]
UniProt Synonym Gene Names
CNCG3; CNG channel alpha-3; CNG-3; CNG3  [Similar Products]
UniProt Entry Name
CNGA3_HUMAN
NCBI Summary for CNGA3
This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for CNGA3
CNGA3: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. Defects in CNGA3 are the cause of achromatopsia type 2 (ACHM2); also known as total colorblindness or rod monochromacy (RMCH2). ACHM2 is an autosomal recessive condition characterized by day blindness and photophobia. In ACHM2 patients the cones are defective and the subjects see better at night. Defects in CNGA3 may be a cause of Leber congenital amaurosis (LCA), a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near- absent pupillary responses, photophobia, high hyperopia and keratoconus. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: integral to plasma membrane

Molecular Function: cGMP binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; ligand-gated ion channel activity; voltage-gated potassium channel activity

Biological Process: cation transport; regulation of membrane potential; signal transduction; transport

Disease: Achromatopsia 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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