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CNGB3 elisa kit :: Human Cyclic nucleotide gated cation channel beta 3 (CNGB3) ELISA Kit

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Catalog # MBS7206890
Unit / Price
  48-Strip-Wells  /  $440 +1 FREE 8GB USB
  96-Strip-Wells  /  $640 +1 FREE 8GB USB
  5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
  10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
Typical Testing Data/Standard Curve (for reference only)
Product Name

Cyclic nucleotide gated cation channel beta 3 (CNGB3), ELISA Kit

Popular Item
Also Known As

Human Cyclic nucleotide gated cation channel beta 3 (CNGB3) ELISA Kit

Product Synonym Names
Human Cyclic nucleotide gated cation channel b 3 (CNGB3) ELISA Kit
Product Gene Name
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
MBS7206890 MSDS
OMIM
605080
Species Reactivity
Specificity
This assay has high sensitivity and excellent specificity for detection of CNGB3. No significant cross-reactivity or interference between CNGB3 and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between CNGB3 and all the analogues, therefore, cross reaction may still exist in some cases.
Samples
Serum, plasma, cell culture supernatants, body fluid and tissue homogenate
Sensitivity
0.1 ng/mL
Preparation and Storage
Store all reagents at 2-8 degree C.
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of CNGB3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forCNGB3purchase
MBS7206890 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cyclic nucleotide gated cation channel beta 3 (CNGB3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CNGB3. The ELISA analytical biochemical technique of the MBS7206890 kit is based on CNGB3 antibody-CNGB3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CNGB3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CNGB3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Related Product Information for
CNGB3 elisa kit
Intended Uses: This CNGB3 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human CNGB3. This ELISA kit for research use only, not for therapeutic or diagnostic applications!
Product Categories/Family for CNGB3 elisa kit

Typical Testing Data/Standard Curve (for reference only) of CNGB3 elisa kit
CNGB3 elisa kit Typical Testing Data/Standard Curve (for reference only) image
Sample Manual Insert of MBS7206890. Click to request current manual
NCBI/Uniprot data below describe general gene information for CNGB3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,633 Da
NCBI Official Full Name
cyclic nucleotide-gated cation channel beta-3
NCBI Official Synonym Full Names
cyclic nucleotide gated channel beta 3
NCBI Official Symbol
CNGB3  [Similar Products]
NCBI Official Synonym Symbols
ACHM1
  [Similar Products]
NCBI Protein Information
cyclic nucleotide-gated cation channel beta-3; CNG channel beta-3; cone photoreceptor cGMP-gated cation channel beta-subunit; cyclic nucleotide-gated cation channel modulatory subunit
UniProt Protein Name
Cyclic nucleotide-gated cation channel beta-3
UniProt Synonym Protein Names
Cone photoreceptor cGMP-gated channel subunit beta; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-3; CNG channel beta-3
UniProt Gene Name
CNGB3  [Similar Products]
UniProt Synonym Gene Names
CNG channel beta-3  [Similar Products]
UniProt Entry Name
CNGB3_HUMAN
NCBI Summary for CNGB3
This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]
UniProt Comments for CNGB3
CNGB3: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. Defects in CNGB3 are the cause of Stargardt disease type 1 (STGD1). STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD1 inheritance is autosomal recessive. Defects in CNGB3 are the cause of achromatopsia type 3 (ACHM3); also known as Pingelapese blindness. ACHM3 is a congenital complete achromatopsia and is distinct from total colorblindness mainly because of the consistent concurrence of severe myopia. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation

Chromosomal Location of Human Ortholog: 8q21.3

Cellular Component: photoreceptor outer segment; integral to plasma membrane

Molecular Function: voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; cGMP binding

Biological Process: phototransduction, visible light; regulation of membrane potential; visual perception; transport; signal transduction; cation transport

Disease: Achromatopsia 3; Stargardt Disease 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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