• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-CNOT2 antibody :: Rabbit CNOT2 (Ab-101) Antibody

Scan QR to view Datasheet
Catalog # MBS000005
Unit / Price
  0.05 mL  /  $270 +1 FREE 8GB USB
  0.1 mL  /  $445 +1 FREE 8GB USB
anti-CNOT2 antibody
Product Name

CNOT2 (Ab-101), Antibody

Also Known As

Rabbit CNOT2 (Ab-101) Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
540
Chromosome Location
Chromosome: 12; NC_000012.11 (70636774..70748773). Location: 12q15
OMIM
604909
3D Structure
ModBase 3D Structure for Q9NZN8
Host
Rabbit
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-CNOT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CNOT2 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for CNOT2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,738 Da
NCBI Official Full Name
CCR4-NOT transcription complex subunit 2
NCBI Official Synonym Full Names
CCR4-NOT transcription complex, subunit 2
NCBI Official Symbol
CNOT2  [Similar Products]
NCBI Official Synonym Symbols
NOT2; CDC36; NOT2H; HSPC131
  [Similar Products]
NCBI Protein Information
CCR4-NOT transcription complex subunit 2; CCR4-associated factor 2; negative regulator of transcription 2
UniProt Protein Name
CCR4-NOT transcription complex subunit 2
UniProt Synonym Protein Names
CCR4-associated factor 2
UniProt Gene Name
CNOT2  [Similar Products]
UniProt Synonym Gene Names
CDC36; NOT2  [Similar Products]
UniProt Entry Name
CNOT2_HUMAN
NCBI Summary for CNOT2
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for CNOT2
NOT2: The CCR4-NOT complex functions as general transcription regulation complex. Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Belongs to the CNOT2/3/5 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: membrane; cytoplasm; nucleus; cytosol; CCR4-NOT complex

Molecular Function: protein binding; poly(A)-specific ribonuclease activity

Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of translation; transcription from RNA polymerase II promoter; poly(A) tail shortening; gene expression; RNA-mediated gene silencing; negative regulation of transcription from RNA polymerase II promoter; negative regulation of estrogen receptor signaling pathway; mRNA catabolic process, deadenylation-dependent decay; trophectodermal cell differentiation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000