AAH95513.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,858 Da
NCBI Official Full Name
CNR1 protein, partial
NCBI Official Synonym Full Names
cannabinoid receptor 1 (brain)
NCBI Official Synonym Symbols
CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5 [Similar Products]
NCBI Protein Information
cannabinoid receptor 1; central cannabinoid receptor
UniProt Protein Name
Cannabinoid receptor 1
UniProt Synonym Protein Names
CANN6
UniProt Synonym Gene Names
UniProt Entry Name
CNR1_HUMAN
NCBI Summary for CNR1
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
UniProt Comments for CNR1
CNR1: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q14-q15
Cellular Component: growth cone; intracellular membrane-bound organelle; axon; integral to plasma membrane; plasma membrane
Molecular Function: cannabinoid receptor activity; drug binding
Biological Process: response to nicotine; regulation of synaptic transmission, glutamatergic; negative regulation of fatty acid beta-oxidation; maternal process involved in pregnancy; positive regulation of apoptosis; positive regulation of acute inflammatory response to antigenic stimulus; response to morphine; response to lipopolysaccharide; glucose homeostasis; sensory perception of pain; negative regulation of blood pressure; negative regulation of dopamine secretion; response to nutrient; aging; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; axonal fasciculation; negative regulation of action potential; response to cocaine; regulation of synaptic transmission, GABAergic; memory; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; response to ethanol; positive regulation of fever; spermatogenesis; regulation of insulin secretion; positive regulation of blood pressure
Research Articles on CNR1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with CNR1 elisa kit
Diseases associated with CNR1 elisa kit
Organs/Tissues associated with CNR1 elisa kit
|