NP_001193940.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,633 Da
NCBI Official Full Name
ciliary neurotrophic factor receptor subunit alpha preproprotein
NCBI Official Synonym Full Names
ciliary neurotrophic factor receptor
NCBI Protein Information
ciliary neurotrophic factor receptor subunit alpha; CNTFR-alpha; CNTF receptor subunit alpha
UniProt Protein Name
Ciliary neurotrophic factor receptor subunit alpha
UniProt Synonym Gene Names
UniProt Entry Name
CNTFR_HUMAN
NCBI Summary for CNTFR
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
UniProt Comments for CNTFR
CNTFR: Binds to CNTF. The alpha subunit provides the receptor specificity. Belongs to the type I cytokine receptor family. Type 3 subfamily.
Protein type: Receptor, misc.; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: extrinsic to membrane
Molecular Function: cytokine binding; ciliary neurotrophic factor receptor activity; receptor binding
Biological Process: nervous system development; suckling behavior; positive regulation of cell proliferation; negative regulation of neuron apoptosis; signal transduction; sex differentiation
Research Articles on CNTFR
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Products associated with CNTFR elisa kit
Pathways associated with CNTFR elisa kit
Diseases associated with CNTFR elisa kit
Organs/Tissues associated with CNTFR elisa kit
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