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COL12A1 recombinant protein :: Collagen alpha-1(XII) chain Recombinant Protein

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Catalog # MBS1420623
Unit / Price
  0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
SDS-PAGE
Product Name

Collagen alpha-1(XII) chain (COL12A1), Recombinant Protein

Popular Item
Also Known As

Recombinant Human Collagen alpha-1(XII) chain

Product Synonym Names
Homo sapiens (Human)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS1420623 COA
Sequence Positions
140-316aa; Partial
Sequence Length
3063
Sequence
DLVFLVDGSW SVGRNNFKYI LDFIAALVSA FDIGEEKTRV GVVQYSSDTR TEFNLNQYYQ RDELLAAIKK IPYKGGNTMT GDAIDYLVKN TFTESAGARV GFPKVAIIIT DGKSQDEVEI PARELRNVGV EVFSLGIKAA DAKELKQIAS TPSLNHVFNV ANFDAIVDIQ NEIISQV
OMIM
120320
3D Structure
ModBase 3D Structure for Q99715
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of COL12A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
COL12A1 recombinant protein
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
Product Categories/Family for COL12A1 recombinant protein

COL12A1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for COL12A1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23.61kD
NCBI Official Full Name
collagen alpha-1(XII) chain long isoform
NCBI Official Synonym Full Names
collagen type XII alpha 1
NCBI Official Symbol
COL12A1  [Similar Products]
NCBI Official Synonym Symbols
COL12A1L; BA209D8.1; DJ234P15.1
  [Similar Products]
NCBI Protein Information
collagen alpha-1(XII) chain
UniProt Protein Name
Collagen alpha-1(XII) chain
Protein Family
UniProt Gene Name
COL12A1  [Similar Products]
UniProt Synonym Gene Names
COL12A1L  [Similar Products]
UniProt Entry Name
COCA1_HUMAN
NCBI Summary for COL12A1
This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for COL12A1
COL12A1: Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q12-q13

Cellular Component: collagen type XII; endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space

Molecular Function: extracellular matrix structural constituent conferring tensile strength

Biological Process: cell adhesion; collagen catabolic process; collagen fibril organization; extracellular matrix disassembly; extracellular matrix organization and biogenesis; skeletal development

Disease: Bethlem Myopathy 2; Ullrich Congenital Muscular Dystrophy 2
Product References and Citations for COL12A1 recombinant protein
"Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13." Gerecke D.R., Olson P.F., Koch M., Knoll J.H.M., Taylor R., Hudson D.L., Champliaud M.-F., Olsen B.R., Burgeson R.E. Genomics 41:236-242(1997)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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