NP_000485.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
150,419 Da
NCBI Official Full Name
collagen alpha-1(XVII) chain
NCBI Official Synonym Full Names
collagen, type XVII, alpha 1
NCBI Official Synonym Symbols
BP180; BPA-2; BPAG2; LAD-1; BA16H23.2 [Similar Products]
NCBI Protein Information
collagen alpha-1(XVII) chain; collagen alpha-1(XVII) chain; alpha 1 type XVII collagen; type XVII collagen alpha-1; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type XVII, alpha 1 (BP180))
UniProt Protein Name
Collagen alpha-1(XVII) chain
UniProt Synonym Protein Names
180 kDa bullous pemphigoid antigen 2; Bullous pemphigoid antigen 2Cleaved into the following 2 chains:120 kDa linear IgA disease antigen; Alternative name(s):; 120 kDa linear IgA dermatosis antigen; Linear IgA disease antigen 1; LAD-197 kDa linear IgA disease antigen; Alternative name(s):; 97 kDa linear IgA bullous dermatosis antigen; 97 kDa LAD antigen; 97-LAD; Linear IgA bullous disease antigen of 97 kDa
UniProt Synonym Gene Names
UniProt Entry Name
COHA1_HUMAN
NCBI Summary for COL17
This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]
UniProt Comments for COL17
COL17A1: May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. Defects in COL17A1 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). GABEB is a non- lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Extracellular matrix; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q24.3
Cellular Component: collagen; hemidesmosome; endoplasmic reticulum lumen; integral to plasma membrane; extracellular region; plasma membrane; basement membrane; intercellular junction
Molecular Function: protein binding
Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; epidermis development; hemidesmosome assembly; cell-matrix adhesion
Disease: Epidermolysis Bullosa, Junctional, Non-herlitz Type
Research Articles on COL17
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Products associated with COL17 elisa kit
Pathways associated with COL17 elisa kit
Diseases associated with COL17 elisa kit
Organs/Tissues associated with COL17 elisa kit
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