NP_076932.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,200 Da
NCBI Official Full Name
collectin-11 isoform a
NCBI Official Synonym Full Names
collectin subfamily member 11
NCBI Official Synonym Symbols
3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb [Similar Products]
NCBI Protein Information
collectin-11
UniProt Protein Name
Collectin-11
UniProt Synonym Protein Names
Collectin kidney protein 1; CL-K1
UniProt Synonym Gene Names
UniProt Entry Name
COL11_HUMAN
NCBI Summary for COLEC11
This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for COLEC11
COLEC11: Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration. Defects in COLEC11 are the cause of 3MC syndrome type 2 (3MC2). 3MC2 is an a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly archedDE eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the COLEC10/COLEC11 family. 9 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p25.3
Cellular Component: collagen; extracellular region
Molecular Function: mannose binding
Biological Process: developmental process; multicellular organismal development; receptor-mediated endocytosis
Disease: 3mc Syndrome 2
Research Articles on COLEC11
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Products associated with COLEC11 elisa kit
Pathways associated with COLEC11 elisa kit
Diseases associated with COLEC11 elisa kit
Organs/Tissues associated with COLEC11 elisa kit
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