NP_001293.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,532 Da
NCBI Official Full Name
cortistatin preproprotein
NCBI Official Synonym Full Names
cortistatin
NCBI Protein Information
cortistatin; cortistatin-14; cortistatin-17; cortistatin-29; preprocortistatin; prepro-cortistatin
UniProt Protein Name
Cortistatin
UniProt Synonym Gene Names
UniProt Entry Name
CORT_HUMAN
NCBI Summary for CORT
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]
UniProt Comments for CORT
Function: Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
Research Articles on CORT
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Products associated with CORT elisa kit
Pathways associated with CORT elisa kit
Diseases associated with CORT elisa kit
Organs/Tissues associated with CORT elisa kit
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