NP_003777.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
64,632 Da
NCBI Official Full Name
canalicular multispecific organic anion transporter 2 isoform 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 3
NCBI Official Synonym Symbols
MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757 [Similar Products]
NCBI Protein Information
canalicular multispecific organic anion transporter 2
UniProt Protein Name
Canalicular multispecific organic anion transporter 2
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3
UniProt Synonym Gene Names
UniProt Entry Name
MRP3_HUMAN
NCBI Summary for ABCC3
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC3
ABCC3: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 17q22
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: anion transmembrane-transporting ATPase activity; ATP binding; ATPase activity, coupled to transmembrane movement of substances; bile acid-exporting ATPase activity; organic anion transmembrane transporter activity
Biological Process: bile acid and bile salt transport; metabolic process; transmembrane transport; transport
Research Articles on ABCC3
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Pathways associated with ABCC3 blocking peptide
Diseases associated with ABCC3 blocking peptide
Organs/Tissues associated with ABCC3 blocking peptide
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