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CRADD cdna clone

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Catalog # MBS1270640
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
CRADD cdna clone
Product Name


Also Known As


Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
atggaggcca gagacaaaca agtactccgc tcacttcgcc tggagctggg tgcagaggta ttggtggagg gactggttct tcagtacctc taccaggaag gaatcttgac ggaaaaccat attcaagaaa tcaatgctca aaccacaggc ctccggaaaa caatgctcct gctggatatc ctaccttcca ggggccctaa agcatttgat acattcctag attccctaca ggagtttccc tgggtcaggg agaagctgaa gaaggcaagg gaagaggcca tgaccgacct gcctgcaggt gacagattga ctgggatccc ctcgcacatc ctcaacagct ccccatcaga ccggcagatt aaccagctgg cccagaggct gggccctgag tgggagccca tggtgctgtc tctgggactg tcccagacgg atatctaccg ctgtaaggcc aaccaccccc acaacgtgca gtcgcaggtg gtggaggcct tcatccgttg gcggcagcgc ttcgggaagc aggccacctt ccagagcctg cacaacgggc tgcgggctgt ggaggtggac ccctcgctgc tcctgcacat gttggagtga
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of CRADD cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CRADD. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,826 Da
NCBI Official Full Name
Homo sapiens CASP2 and RIPK1 domain containing adaptor with death domain, mRNA
NCBI Official Synonym Full Names
CASP2 and RIPK1 domain containing adaptor with death domain
NCBI Official Symbol
CRADD  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
death domain-containing protein CRADD
UniProt Protein Name
Death domain-containing protein CRADD
UniProt Synonym Protein Names
Caspase and RIP adapter with death domain; RIP-associated protein with a death domain
UniProt Gene Name
CRADD  [Similar Products]
UniProt Synonym Gene Names
RAIDD  [Similar Products]
UniProt Entry Name
NCBI Summary for CRADD
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
UniProt Comments for CRADD
CRADD: Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non- syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.

Protein type: Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 12q21.33-q23.1

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protease binding; protein binding; protein binding, bridging

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; induction of apoptosis via death domain receptors; regulation of apoptosis

Disease: Mental Retardation, Autosomal Recessive 34
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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