NP_001243228.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,122 Da
NCBI Official Full Name
corticotropin-releasing factor receptor 1 isoform 5
NCBI Official Synonym Full Names
corticotropin releasing hormone receptor 1
NCBI Official Synonym Symbols
CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRHR1f; CRF-R-1; CRH-R-1; CRH-R1h [Similar Products]
NCBI Protein Information
corticotropin-releasing factor receptor 1; CRH receptor 1 variant B; seven transmembrane helix receptor; corticotropin-releasing hormone receptor 1; corticotropin-releasing factor type 1 receptor; corticotropin releasing hormone receptor variant 1e; corticotropin releasing hormone receptor variant 1g
UniProt Protein Name
Corticotropin-releasing factor receptor 1
UniProt Synonym Protein Names
Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1
UniProt Synonym Gene Names
UniProt Entry Name
CRFR1_HUMAN
NCBI Summary for CRH-R
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346. [provided by RefSeq, Jan 2012]
UniProt Comments for CRH-R
CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: multivesicular body; cell soma; apical part of cell; integral to plasma membrane; dendrite; plasma membrane; integral to membrane; trans-Golgi network; vesicle; intrinsic to plasma membrane
Molecular Function: protein binding; corticotropin-releasing hormone binding; corticotropin-releasing hormone receptor activity; protein complex binding; G-protein alpha-subunit binding; corticotrophin-releasing factor receptor activity
Biological Process: fear response; hypothalamus development; hormone-mediated signaling; adrenal gland development; adenylate cyclase activation; positive regulation of mast cell degranulation; behavioral response to ethanol; female pregnancy; memory; behavioral response to pain; general adaptation syndrome, behavioral process; elevation of cytosolic calcium ion concentration; epithelial cell differentiation; adrenocorticotropin hormone secretion; neuropeptide signaling pathway; behavioral response to cocaine; response to hypoxia; negative regulation of epinephrine secretion; visual learning; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; parturition; response to electrical stimulus
Research Articles on CRH-R
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Pathways associated with CRH-R elisa kit
Diseases associated with CRH-R elisa kit
Organs/Tissues associated with CRH-R elisa kit
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