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CRK shrna

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Catalog # MBS8269867
Unit / Price DISCONTINUED
CRK shrna
Product Name

CRK, shRNA

Also Known As

CRK shRNA Plasmid (Mouse)

Product Synonym Names
CRKO; Adapter molecule crk; Proto-oncogene c-Crk; p38
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
204
3D Structure
ModBase 3D Structure for Q64010
Host
E Coli
Species Reactivity
Mouse
Specificity
CRK shRNA Plasmid (Mouse) contains 3 different target-specific plasmids each encoding 19-23 nt (plus hairpin) shRNAs designed to knock down gene expression. Each plasmid contains a resistance gene for the selection of cells stably expressing shRNA.
Form/Format
Lyophilized Powder
Quality Control
The sequence of shRNA is guaranteed by sequencing.
Directions for Use
Resuspend lyophilized shRNA plasmid DNA in 500 ul of the deionized water. Each vial contains 50 ug of lyophilized shRNA plasmid DNA. Suitable for up to 50 transfections.
Components
We offer 3 different plasmids which knock down mouse CRK gene specifically. Each vial contains 50 ug of lyophilized shRNA.
Preparation and Storage
Store lyophilized shRNA plasmid DNA at -20 degree C with desiccant. Stable for one year. Once resuspended, store at 4 degree C for short term storage or -80 degree C for long term storage. Avoid repeated freeze thaw cycles.
Other Notes
Small volumes of CRK shrna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CRK shrna
shRNA Plasmid to inhibit CRK expression by RNA interference
Applications Tested/Suitable for CRK shrna
RNA interference (RNAi)
NCBI/Uniprot data below describe general gene information for CRK. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
22,847 Da
NCBI Official Full Name
adapter molecule crk isoform 2
NCBI Official Synonym Full Names
v-crk avian sarcoma virus CT10 oncogene homolog
NCBI Official Symbol
NCBI Official Synonym Symbols
p38; Crk3; Crko; Crk-I; c-Crk; Crk-II; CrkIII; Crk-III
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NCBI Protein Information
adapter molecule crk
UniProt Protein Name
Adapter molecule crk
UniProt Synonym Protein Names
Proto-oncogene c-Crk; p38
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NCBI Summary for CRK
This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013]
UniProt Comments for CRK
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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