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anti-CRMP-2 antibody :: CRMP-2 Antibody

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Catalog # MBS854616
Unit / Price
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  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

CRMP-2, Antibody

Popular Item
Full Product Name

CRMP-2 (Phospho-Thr509) Antibody

Product Synonym Names
Collapsin response mediator protein 2; CRMP2; Dihydropyrimidinase related protein-2; DPYL2; DPYSL2; DRP-2; N2A3; TOAD-64; Turned on after division; 64 kDa protein; ULIP 2 protein; ULIP2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
602463
3D Structure
ModBase 3D Structure for Q16555
Species Reactivity
Human, Mouse, Rat
Specificity
CRMP-2 (Phospho-Thr509) antibody detects endogenous levels of CRMP-2 only when phosphorylated at threonine 509.
Purity/Purification
Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human CRMP-2 around the phosphorylation site of threonine 509 (S-V-TP-PK).
All Sites
Human: Thr509
Mouse: Thr509
Rat: Thr509
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CRMP-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CRMP-2 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-CRMP-2 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:1000

Testing Data of anti-CRMP-2 antibody
P-peptide-+
anti-CRMP-2 antibody Testing Data image
Immunohistochemistry (IHC) of anti-CRMP-2 antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue using CRMP-2 (Phospho-Thr509) antibody. Western blot analysis of extracts from HT-29 cells, treated with heat shock, using CRMP-2 (Phospho-Thr509) antibody.
anti-CRMP-2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CRMP-2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,163 Da
NCBI Official Full Name
dihydropyrimidinase-related protein 2 isoform 1
NCBI Official Synonym Full Names
dihydropyrimidinase like 2
NCBI Official Symbol
DPYSL2  [Similar Products]
NCBI Official Synonym Symbols
DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2
  [Similar Products]
NCBI Protein Information
dihydropyrimidinase-related protein 2
UniProt Protein Name
Dihydropyrimidinase-related protein 2
UniProt Synonym Protein Names
Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2
UniProt Gene Name
DPYSL2  [Similar Products]
UniProt Synonym Gene Names
CRMP2; ULIP2; DRP-2; CRMP-2; ULIP-2  [Similar Products]
NCBI Summary for CRMP-2
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for CRMP-2
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Product References and Citations for anti-CRMP-2 antibody
Miki Y., Science 266:66-71(1994). Smith T.M., Genome Res. 6:1029-1049(1996). Wilson C.A., Oncogene 14:1-16(1997).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-CRMP-2 antibody
 Reference Product  PubMed Publications
 GSK3B antibody  >1 publications with CRMP-2 and GSK3B
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