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anti-CRP antibody :: Goat CRP (C-Reactive Protein) Antibody

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Catalog # MBS390035
Unit / Price
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  0.5 mL  /  $335 +1 FREE 8GB USB
  1 mL  /  $505 +1 FREE 8GB USB
anti-CRP antibody
Product Name

CRP (C-Reactive Protein), Antibody

Full Product Name

HRP-conjugated Goat Anti-Human CRP (C-Reactive Protein)

Product Synonym Names
Horseradish Peroxidase (HRP) conjugated Goat Anti- Human CRP, Polyclonal Antibody
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (159682079..159684396, complement). Location: 1q23.2
OMIM
123260
3D Structure
ModBase 3D Structure for P02741
Host
Goat
Specificity
Specifically binds to C-reactive protein. Dilution for immunoblot and ELISA range: 200 to 4,000.
Form/Format
0.5 ml in Freeze-dried powder.
Concentration
1 mg / ml (lot specific)
Source Note
Polyclonal antibody purified by C-reactive Protein (CRP)-Sepharose affinity column, and conjugated with HRP.
Preservative
50 mM PBS, 0.1M NaCl, pH 7.4 and 0.01% Thimersol.
Stabilizer
10 mg / ml Bovine Serum Albumin.
Preparation and Storage
Freeze-dried product should be stored refrigerated until opened. After opening, restore to 0.5 ml with distilled water. If it is not completely clear after standing for 1-2 Hours at room temperature, centrifuge the product. It is stable for several weeks at 4 degree C as an undiluted liquid. Do not use for more than one day after dilution. For extended storage after reconstitution, we suggest aliquot to avoid repeated freezing and thawing; or the addition of an equal volume of glycerol to make a final glycerol concentration of 50%, followed by storage at -20 degree C. The concentration of protein and buffer salts will decrease to one-half of the original after the addition of glycerol
Other Notes
Small volumes of anti-CRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CRP antibody
Human C-reactive protein (CRP) is an acute phase protein produced by the liver. It is a member of the pentraxin family of proteins with five identical nonglycosylated subunits of 206 amino acids each (m.w. 24 kDa). Among other markers of inflammation, CRP has been showed the strongest association with cardiovascular events. Clinical studies demonstrated that coronary mortality among patients with unstable angina and elevated CRP is significantly higher comparing with the patients without elevated CRP. It is an important biomarker for detecting individuals at high risk of plaque rapture
Product Categories/Family for anti-CRP antibody
Applications Tested/Suitable for anti-CRP antibody
ELISA (EIA), Immunoblot (IB)
Application Notes for anti-CRP antibody
Freeze-dried powder. Dilution for Immunoblot & ELISA range: 1,000 to 4,000.
Use: The antibody can be used for detection of the existence of C-reactive protein, immunoassays and immunoblots.
NCBI/Uniprot data below describe general gene information for CRP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,039 Da
NCBI Official Full Name
C-reactive protein
NCBI Official Synonym Full Names
C-reactive protein, pentraxin-related
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
C-reactive protein; pentraxin 1
UniProt Protein Name
C-reactive protein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
CRP_HUMAN
NCBI Summary for CRP
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
UniProt Comments for CRP
Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Cofactor: Binds 2 calcium ions per subunit.

Subunit structure: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.

Subcellular location: Secreted.

Tissue specificity: Found in plasma.

Induction: The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6//interleukin-6.

Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.

Sequence similarities: Belongs to the pentaxin family.Contains 1 pentaxin domain.

Mass spectrometry: Molecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. Ref.15Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. Ref.15
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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