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CSE recombinant protein :: Cystathionine Gamma Lyase (CSE) Recombinant Protein

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Catalog # MBS2018693 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $150 +1 FREE 8GB USB
  0.05 mg  /  $290 +1 FREE 8GB USB
  0.1 mg  /  $450 +1 FREE 8GB USB
  0.2 mg  /  $560 +1 FREE 8GB USB
  0.5 mg  /  $1,080 +1 FREE 8GB USB
  1 mg  /  $1,605 +2 FREE 8GB USB
Product Name

Cystathionine Gamma Lyase (CSE), Recombinant Protein

Popular Item
Also Known As

Recombinant Cystathionine Gamma Lyase (CSE)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 3; NC_000069.6 (157894248..157925081, complement). Location: 3 H4; 3
3D Structure
ModBase 3D Structure for Q8VCN5
E. coli
Species Reactivity
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
200ug/mL (lot specific)
Prokaryotic expression
N-terminal His-Tag
Tissue Specificity
Liver, Kidney
Subcellular Location
Freeze-dried powder
Predicted isoelectric point
Predicted Molecular Mass
Accurate Molecular Mass
27kDa as determined by SDS-PAGE reducing conditions
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Other Notes
Small volumes of CSE recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for CSE recombinant protein
SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling.

(May be suitable for use in other assays to be determined by the end user.)

Sequence Information of CSE recombinant protein
CSE recombinant protein Sequence Information image
NCBI/Uniprot data below describe general gene information for CSE. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cystathionine gamma-lyase
NCBI Official Synonym Full Names
cystathionase (cystathionine gamma-lyase)
NCBI Official Symbol
NCBI Official Synonym Symbols
CSE; Cys3; AI314617; BC019483; 0610010I13Rik
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NCBI Protein Information
cystathionine gamma-lyase; gamma-cystathionase; cysteine-protein sulfhydrase
UniProt Protein Name
Cystathionine gamma-lyase
UniProt Synonym Protein Names
Cysteine-protein sulfhydrase; Gamma-cystathionase
UniProt Gene Name
UniProt Entry Name
UniProt Comments for CSE
CTH: Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. Defects in CTH are the cause of cystathioninuria (CSTNU). It is an autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion. Belongs to the trans-sulfuration enzymes family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Other Amino Acids Metabolism - selenoamino acid; Cell cycle regulation; Energy Metabolism - nitrogen; Amino Acid Metabolism - cysteine and methionine; Lyase; EC

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: calmodulin binding; protein binding; cystathionine gamma-lyase activity; cystathionine beta-lyase activity; lyase activity; catalytic activity; pyridoxal phosphate binding

Biological Process: negative regulation of cell proliferation; glutathione metabolic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; cysteine biosynthetic process; homocysteine metabolic process; amino acid biosynthetic process; negative regulation of cell growth; negative regulation of apoptosis; activation of NF-kappaB transcription factor; protein homotetramerization
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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