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anti-CSFR antibody :: CSFR Antibody

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Catalog # MBS859460
Unit / Price
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  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

CSFR, Antibody

Popular Item
Full Product Name

CSFR (Ab-561) Antibody

Product Synonym Names
CD115; CSF-1-R; CSF1R; CSFMR; EC 2.7.10.1; FMS; Fms proto-oncogene; M-CSFR; Macrophage colony stimulating factor I receptor precursor; c-fms; kinase CSFR
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
164770
3D Structure
ModBase 3D Structure for P07333
Species Reactivity
Human, Mouse, Rat
Specificity
CSFR (Ab-561) antibody detects endogenous levels of total CSFR protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from Internal of human CSFR.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CSFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CSFR antibody
Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-CSFR antibody
IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:5000

Testing Data of anti-CSFR antibody
Peptide-+
anti-CSFR antibody Testing Data image
Immunohistochemistry (IHC) of anti-CSFR antibody
Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using CSFR (Ab-561) antibody. Immunofluorescence analysis of HeLa cells, using CSFR (Ab-561) antibody.
anti-CSFR antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CSFR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,248 Da
NCBI Official Full Name
macrophage colony-stimulating factor 1 receptor
NCBI Official Synonym Full Names
colony stimulating factor 1 receptor
NCBI Official Symbol
CSF1R  [Similar Products]
NCBI Official Synonym Symbols
FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; M-CSF-R
  [Similar Products]
NCBI Protein Information
macrophage colony-stimulating factor 1 receptor
UniProt Protein Name
Macrophage colony-stimulating factor 1 receptor
UniProt Synonym Protein Names
CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115
UniProt Gene Name
CSF1R  [Similar Products]
UniProt Synonym Gene Names
FMS; CSF-1-R; CSF-1R; M-CSF-R  [Similar Products]
NCBI Summary for CSFR
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017]
UniProt Comments for CSFR
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
Product References and Citations for anti-CSFR antibody
Hampe A., Oncogene Res. 4:9-17(1989). Andre C., Genomics 39:216-226(1997). Liu T., J. Proteome Res. 4:2070-2080(2005).

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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