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CSNK1E cdna clone

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Catalog # MBS1276843
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
CSNK1E cdna clone
Product Name

CSNK1E, cDNA Clone

Popular Item
Full Product Name

CSNK1E cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggagctac gtgtggggaa caagtaccgc ctgggacgga agatcgggag cgggtccttc ggagatatct acctgggtgc caacatcgcc tctggtgagg aagtcgccat caagctggag tgtgtgaaga caaagcaccc ccagctgcac atcgagagca agttctacaa gatgatgcag ggtggcgtgg ggatcccgtc catcaagtgg tgcggagctg agggcgacta caacgtgatg gtcatggagc tgctggggcc tagcctcgag gacctgttca acttctgttc ccgcaaattc agcctcaaga cggtgctgct cttggccgac cagatgatca gccgcatcga gtatatccac tccaagaact tcatccaccg ggacgtcaag cccgacaact tcctcatggg gctggggaag aagggcaacc tggtctacat catcgacttc ggcctggcca agaagtaccg ggacgcccgc acccaccagc acattcccta ccgggaaaac aagaacctga ccggcacggc ccgctacgct tccatcaaca cgcacctggg cattgagcaa agccgtcgag atgacctgga gagcctgggc tacgtgctca tgtacttcaa cctgggctcc ctgccctggc aggggctcaa agcagccacc aagcgccaga agtatgaacg gatcagcgag aagaagatgt caacgcccat cgaggtcctc tgcaaaggct atccctccga attctcaaca tacctcaact tctgccgctc cctgcggttt gacgacaagc ccgactactc ttacctacgt cagctcttcc gcaacctctt ccaccggcag ggcttctcct atgactacgt ctttgactgg aacatgctga aattcggtgc agcccggaat cccgaggatg tggaccggga gcggcgagaa cacgaacgcg aggagaggat ggggcagcta cgggggtccg cgacccgagc cctgccccct ggcccaccca cgggggccac tgccaaccgg ctccgcagtg ccgccgagcc cgtggcttcc acgccagcct cccgcatcca gccggctggc aatacttctc ccagagcgat ctcgcgggtc gaccgggaga ggaaggtgag tatgaggctg cacaggggtg cgcccgccaa cgtctcctcc tcagacctca ctgggcggca agaggtctcc cggatcccag cctcacagac aagtgtgcca tttgaccatc tcgggaagtg a
OMIM
600863
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CSNK1E cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CSNK1E. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Related Accession #
Molecular Weight
47,315 Da
NCBI Official Full Name
Homo sapiens casein kinase 1, epsilon, mRNA
NCBI Official Synonym Full Names
casein kinase 1 epsilon
NCBI Official Symbol
CSNK1E  [Similar Products]
NCBI Official Synonym Symbols
HCKIE; CKIepsilon
  [Similar Products]
NCBI Protein Information
casein kinase I isoform epsilon
UniProt Protein Name
Casein kinase I isoform epsilon
Protein Family
UniProt Gene Name
CSNK1E  [Similar Products]
UniProt Synonym Gene Names
CKI-epsilon; CKIe  [Similar Products]
UniProt Entry Name
KC1E_HUMAN
NCBI Summary for CSNK1E
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
UniProt Comments for CSNK1E
CK1E: an ubiquitous protein kinase of the CK1 family. Together with Dvl-1 and Frat-1 activate the Wnt signaling pathway. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. May play a role in cell cycle progression. Two splice variant isoforms have been described. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CK1-D and/or CK1-E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with SOCS3. Mutations in hamster and Drosophila orthologs have circadian rhythm phenotypes, and the circadian gene period (per) is a substrate in both human and fly. A coding SNP variant in human, which increases CK1 activity, is negatively associated with circadian disorder. LOF mutations and LOH seen in mammary ductal carcinoma.

Protein type: EC 2.7.11.1; Protein kinase, CK1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: circadian regulation of gene expression; DNA repair; endocytosis; G2/M transition of mitotic cell cycle; negative regulation of protein binding; peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cell shape; regulation of circadian rhythm; rRNA processing; signal transduction; Wnt receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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