P10605.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,280 Da
NCBI Official Full Name
Cathepsin B
NCBI Official Synonym Full Names
cathepsin B
NCBI Official Synonym Symbols
NCBI Protein Information
cathepsin B; cathepsin B1
UniProt Protein Name
Cathepsin B
UniProt Synonym Protein Names
Cathepsin B1Cleaved into the following 2 chains:Cathepsin B light chain; Cathepsin B heavy chain
UniProt Entry Name
CATB_MOUSE
NCBI Summary for CTSB
This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]
UniProt Comments for CTSB
CTSB: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family.
Protein type: Motility/polarity/chemotaxis; EC 3.4.22.1; Protease; Autophagy
Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; mitochondrion; lysosome; extracellular region; caveola; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; nucleolus; sarcolemma; external side of plasma membrane
Molecular Function: peptidase activity; collagen binding; proteoglycan binding; protein self-association; hydrolase activity; cysteine-type endopeptidase activity; endopeptidase activity; protein complex binding; kininogen binding; peptide binding; cysteine-type peptidase activity
Biological Process: collagen catabolic process; proteolysis involved in cellular protein catabolic process; regulation of catalytic activity; decidualization; proteolysis
Research Articles on CTSB
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Pathways associated with CTSB elisa kit
Diseases associated with CTSB elisa kit
Organs/Tissues associated with CTSB elisa kit
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