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CTSG native protein :: Cathepsin G Native Protein

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Catalog # MBS537015
Unit / Price
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  0.1 mg  /  $400 +1 FREE 8GB USB
CTSG native protein
Product Name

Cathepsin G (CTSG), Native Protein

Popular Item
Full Product Name

Cathepsin G protein

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
116830
3D Structure
ModBase 3D Structure for P08311
Host
Human Neutrophil
Purity/Purification
>98% pure by SDS-PAGE
Form/Format
Lyophilized-salt free. Reconstitute with 50mM Na Acetate, pH 5.5 with 150mM NaCl.
Protein Type
Native
Biological Significance
Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. This enzyme degrades collagen and proteoglycan and can also cause the release of angiotensin II from angiotensin I or angiotensinogen. It has been implicated in connective tissue diseases such as emphysema and rheumatoid arthritis.
Bioactivity
2-4 units/mg - One unit of activity is defined as the amount of enzyme that hydrolyzes one micromole of Suc-ala-ala-pro-phe-pNA (1mM) per minute at 25o C in 160 mM Tris-HCl, pH 7.4, with 1.6 M NaCl.
Contaminants
None detected by SDS-PAGE
Grade
Immunogen
Biohazard Information
Donor samples were tested and found to be negative for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
Additional Remarks
Biological activity = 2-4 Units/mg. 1 unit of activity is defined as the amount of enzyme that hydrolyzes 1 uM per minute.
Preparation and Storage
4 degree C shipping only. Upon receipt store at -20 degree C.
Other Notes
Small volumes of CTSG native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CTSG native protein
Purified native Human Cathepsin G protein
Applications Tested/Suitable for CTSG native protein
User optimized
NCBI/Uniprot data below describe general gene information for CTSG. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cathepsin G
NCBI Official Synonym Full Names
cathepsin G
NCBI Official Symbol
NCBI Official Synonym Symbols
CG; CATG
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NCBI Protein Information
cathepsin G
UniProt Protein Name
Cathepsin G
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
CATG_HUMAN
NCBI Summary for CTSG
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]
UniProt Comments for CTSG
CTSG: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride. Belongs to the peptidase S1 family.

Protein type: Motility/polarity/chemotaxis; Protease; EC 3.4.21.20

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: extracellular matrix; extracellular space; cell surface; plasma membrane; extracellular region; nucleus; secretory granule

Molecular Function: heparin binding; peptidase activity; serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; positive regulation of immune response; extracellular matrix organization and biogenesis; cellular protein metabolic process; protein processing; response to lipopolysaccharide; immune response; proteolysis; angiotensin maturation; defense response to fungus
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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