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CTSK recombinant protein :: Cathepsin K Recombinant Protein

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Catalog # MBS957808
Unit / Price
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  0.01 mg (E-Coli)  /  $160 +1 FREE 8GB USB
  0.01 mg (Yeast)  /  $175 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $200 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $225 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $295 +1 FREE 8GB USB
  0.1 mg (Yeast)  /  $355 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $480 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $565 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $790 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $925 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,215 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,410 +1 FREE 8GB USB
SDS-PAGE
Product Name

Cathepsin K (CTSK), Recombinant Protein

Popular Item
Full Product Name

Recombinant Human Cathepsin K

Product Synonym Names
Cathepsin O; Cathepsin O2; Cathepsin X
Product Synonym Gene Name
CTSO; CTSO2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
115-329aa; Full Length
Sequence
APDSVDYRKK GYVTPVKNQG QCGSCWAFSS VGALEGQLKK KTGKLLNLSP QNLVDCVSEN DGCGGGYMTN AFQYVQKNRG IDSEDAYPYV GQEESCMYNP TGKAAKCRGY REIPEGNEKA LKRAVARVGP VSVAIDASLT SFQFYSKGVY YDESCNSDNL NHAVLAVGYG IQKGNKHWII KNSWGENWGN KGYILMARNK NNACGIANLA SFPKM
OMIM
265800
3D Structure
ModBase 3D Structure for P43235
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of CTSK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CTSK recombinant protein
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
Product Categories/Family for CTSK recombinant protein

CTSK recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for CTSK. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25.5kD
NCBI Official Full Name
cathepsin K preproprotein
NCBI Official Synonym Full Names
cathepsin K
NCBI Official Symbol
NCBI Official Synonym Symbols
CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2
  [Similar Products]
NCBI Protein Information
cathepsin K
UniProt Protein Name
Cathepsin K
UniProt Synonym Protein Names
Cathepsin O; Cathepsin O2; Cathepsin X
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CTSO; CTSO2  [Similar Products]
UniProt Entry Name
CATK_HUMAN
NCBI Summary for CTSK
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
UniProt Comments for CTSK
CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family.

Protein type: EC 3.4.22.38; Protease

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular region; extracellular space; lysosome

Molecular Function: collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; protein binding; proteoglycan binding

Biological Process: bone resorption; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; innate immune response; intramembranous ossification; proteolysis; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway

Disease: Pycnodysostosis
Product References and Citations for CTSK recombinant protein
Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.Shi G.-P., Chapman H.A., Bhairi S.M., Deleeuw C., Reddy V.Y., Weiss S.J.FEBS Lett. 357:129-134(1995) Molecular cloning of human cDNA for cathepsin K novel cysteine proteinase predominantly expressed in bone.Inaoka T., Bilbe G., Ishibashi O., Tezuka K., Kumegawa M., Kokubo T.Biochem. Biophys. Res. Commun. 206:89-96(1995) Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas.Li Y., Alexander M., Wucherpfennig A.L., Yelick P., Chen W., Stashenko P.J. Bone Miner. Res. 10:1197-1202(1995) Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution.Broemme D., Okamoto K.Biol. Chem. Hoppe-Seyler 376:379-384(1995) Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Crystal structure of human cathepsin K complexed with a potent inhibitor.McGrath M.E., Klaus J.L., Barnes M.G., Bromme D.Nat. Struct. Biol. 4:105-109(1997) Design of potent and selective human cathepsin K inhibitors that span the active site.Thompson S.K., Halbert S.M., Bossard M.J., Tomaszek T.A., Levy M.A., Zhao B., Smith W.W., Abdel-Meguid S.S., Janson C.A., D'Alessio K.J., McQueney M.S., Amegadzie B.Y., Hanning C.R., Desjarlais R.L., Briand J., Sarkar S.K., Huddleston M.J., Ijames C.F., Carr S.A., Garnes K.T., Shu A., Heys J.R., Bradbeer J., Zembryki D., Veber D.F.Proc. Natl. Acad. Sci. U.S.A. 94:14249-14254(1997) The crystal structure of human procathepsin K.LaLonde J.M., Zhao B., Janson C.A., D'Alessio K.J., McQueney M.S., Orsini M.J., Debouck C.M., Smith W.W.Biochemistry 38:862-869(1999) Crystal structure of wild-type human procathepsin K.Sivaraman J., Lalumiere M., Menard R., Cygler M.Protein Sci. 8:283-290(1999) Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.Gelb B.D., Shi G.-P., Chapman H.A., Desnick R.J.Science 273:1236-1238(1996) Paternal uniparental disomy for chromosome 1 revealed by molecular analysis of a patient with pycnodysostosis.Gelb B.D., Willner J.P., Dunn T.M., Kardon N.B., Verloes A., Poncin J., Desnick R.J.Am. J. Hum. Genet. 62:848-854(1998) Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein.Ho N., Punturieri A., Wilkin D., Szabo J., Johnson M., Whaley J., Davis J., Clark A., Weiss S., Francomano C.J. Bone Miner. Res. 14:1649-1653(1999) Cathepsin K gene mutations and 1q21 haplotypes in at patients with pycnodysostosis in an outbred population.Haagerup A., Hertz J.M., Christensen M.F., Binderup H., Kruse T.A.Eur. J. Hum. Genet. 8:431-436(2000)

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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