NP_001074553.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
399,097 Da
NCBI Official Full Name
cubilin
NCBI Official Synonym Full Names
cubilin (intrinsic factor-cobalamin receptor)
NCBI Protein Information
cubilin
UniProt Protein Name
Cubilin
UniProt Synonym Protein Names
Intrinsic factor-cobalamin receptor
UniProt Synonym Gene Names
UniProt Comments for Cubn
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
Research Articles on Cubn
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Products associated with Cubn recombinant protein
Pathways associated with Cubn recombinant protein
Diseases associated with Cubn recombinant protein
Organs/Tissues associated with Cubn recombinant protein
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