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anti-CX43 antibody :: Connexin 43 Antibody

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Catalog # MBS856051
Unit / Price
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  0.1 mg  /  $215 +1 FREE 8GB USB
Product Name

Connexin 43 (CX43), Antibody

Popular Item
Full Product Name

Connexin 43 Antibody

Product Synonym Names
CXA1; CXN-43; GJA1; Gap junction 43 kDa heart protein; Gap junction alpha-1 protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
104100
3D Structure
ModBase 3D Structure for P17302
Species Reactivity
Human, Mouse, Rat
Specificity
Connexin 43 antibody detects endogenous levels of total Connexin 43 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from human Connexin 43.
Preparation and Storage
Store at -20°C for 1 year
Other Notes
Small volumes of anti-CX43 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for CX43purchase
Connexin 43 is listed in NCBI and UniProt data bases as gap junction alpha-1 protein, gap junction 43 kDa heart protein, Cx43, GJA1 and GJAL.

Connexin 43 is one of major integral membrane proteins that form gap junction channels to provide inter-cellular communication such as exchange of small molecules and ions between adjacent cells. It’s expressed in variable cell types and plays important role in development, differentiation, and metabolic homeostasis.

Rabbit polyclonal antibodies against connexin 43 were raised using synthetic polypeptide immunogen.

Product contains immunoglobulin G (IgG) fraction of rabbit antiserum purified by affinity chromatography; antibodies are supplied in phosphate buffer with 150mM NaCl, 0.02% NaN3 and 50% glycerol, at pH 7.4.

Intended use of these antibodies include following applications: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) and ELISA (EIA).

Rabbit polyclonal anti-connexin 43 antibodies recognize human, mouse and rat forms of connexin 43.

Antibodies must be stored frozen at -20°C and are stable for 1 year from its’ date of manufacturing.
Applications Tested/Suitable for anti-CX43 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-CX43 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:10000

Immunohistochemistry (IHC) of anti-CX43 antibody
Peptide-+ Immunohistochemical analysis of paraffin-embedded human brain tissue using Connexin 43 antibody.
anti-CX43 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-CX43 antibody
Western blot analysis of extracts from A549 cells, using Connexin 43 antibody.
anti-CX43 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-CX43 antibody
Peptide-+ Immunofluorescence analysis of A549 cells, Connexin 43 antibody
anti-CX43 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for CX43. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
gap junction alpha-1 protein
NCBI Official Synonym Full Names
gap junction protein alpha 1
NCBI Official Symbol
NCBI Official Synonym Symbols
HSS; CMDR; CX43; EKVP; GJAL; ODDD; AVSD3; EKVP3; HLHS1; PPKCA
  [Similar Products]
NCBI Protein Information
gap junction alpha-1 protein
UniProt Protein Name
Gap junction alpha-1 protein
UniProt Synonym Protein Names
Connexin-43; Cx43; Gap junction 43 kDa heart protein
UniProt Gene Name
UniProt Synonym Gene Names
GJAL; Cx43  [Similar Products]
NCBI Summary for CX43
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]
UniProt Comments for CX43
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles ().
Product References and Citations for anti-CX43 antibody
Toshihiko Toyofuku, J. Biol. Chem., May 1998; 273: 12725. Toshihiko Toyofuku, J. Biol. Chem., Jan 1998; 273: 1519. Masayuki Shimada, Biol Reprod, Apr 2001; 64: 1255. Merry L. Lindsey, Circulation, Jun 2006; 113: 2919-2928.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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