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CXCR1 recombinant protein :: C-X-C chemokine receptor type 1 (CXCR1) Recombinant Protein

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Catalog # MBS948697
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SDS-PAGE
Product Name

C-X-C chemokine receptor type 1 (CXCR1), Recombinant Protein

Popular Item
Full Product Name

Recombinant Human C-X-C chemokine receptor type 1 (CXCR1)

Product Synonym Names
Recombinant C-X-C chemokine receptor type 1 (CXCR1); C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; CDw128a High affinity interleukin-8 receptor A; IL-8R A IL-8 receptor type 1 CD_antigen= CD181
Product Synonym Gene Name
CXCR1; CMKAR1, IL8RA[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-39
Sequence
MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNK
Chromosome Location
Chromosome: 2; NC_000002.11 (219027568..219031716, complement). Location: 2q35
OMIM
146929
3D Structure
ModBase 3D Structure for P25024
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90%(SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C. Notes ? Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CXCR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CXCR1 recombinant protein
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

CXCR1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for CXCR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
C-X-C chemokine receptor type 1
NCBI Official Synonym Full Names
chemokine (C-X-C motif) receptor 1
NCBI Official Symbol
CXCR1  [Similar Products]
NCBI Official Synonym Symbols
C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1
  [Similar Products]
NCBI Protein Information
C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; IL-8R A; IL-8 receptor type 1; interleukin 8 receptor, alpha; interleukin-8 receptor type 1; interleukin-8 receptor type A; high affinity interleukin-8 receptor A
UniProt Protein Name
C-X-C chemokine receptor type 1
UniProt Synonym Protein Names
CDw128a; High affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1
Protein Family
UniProt Gene Name
CXCR1  [Similar Products]
UniProt Synonym Gene Names
CMKAR1; IL8RA; CXC-R1; CXCR-1; IL-8R A  [Similar Products]
UniProt Entry Name
CXCR1_HUMAN
NCBI Summary for CXCR1
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
UniProt Comments for CXCR1
IL8RA: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; Receptor, cytokine; GPCR, family 1

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; interleukin-8 receptor activity; chemokine receptor activity; interleukin-8 binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell surface receptor linked signal transduction; receptor internalization; dendritic cell chemotaxis; chemotaxis; inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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