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CYP19A assay kit :: Eukaryotes Aromatase (CYP19A) Assay Kit

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Catalog # MBS846915
Unit / Price
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  100 Assays  /  $635 +1 FREE 8GB USB
CYP19A assay kit
Product Name

Aromatase (CYP19A), Assay Kit

Full Product Name

Aromatase (CYP19A) Inhibitor Screening Kit (Fluorometric)

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Species Reactivity
Preparation and Storage
Store at -20 degree C for 12 months.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of CYP19A assay kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CYP19A assay kit
Background/Introduction: Aromatase (CYP19A, EC 1.14.14.14) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. Aromatase plays a critical role in steroidogenesis, catalyzing the conversion of androgenic hormones into estrogens. The enzyme is expressed in high levels in reproductive tissues, placenta, brain and adipose tissue and is responsible for mammalian sexual dimorphism and development of secondary sexual characteristics. Inhibitors of aromatase are used to treat estrogen-dependent breast cancer, as estrogens promote the expression of peptide growth factors responsible for tumorigenesis. Aromatase activity and expression can be affected by many organic environmental pollutants such as pesticides and plasticizers. Such compounds, known as endocrine disruptors, are suspected of causing precocious puberty, obesity, infertility and various cancers. Aromatase Inhibitor Screening Kit enables rapid screening of drugs and other small molecules for compound-Aromatase interaction in a reliable, high-throughput fluorescence-based assay. The assay utilizes a fluorogenic substrate that is converted into a highly fluorescent metabolite detected in the visible range (Ex/Em = 488/527 nm), ensuring a high signal-to-background ratio with little interference by autofluorescence. The kit contains a complete set of reagents sufficient for performing 100 reactions in a 96-well plate format.
Application Notes for CYP19A assay kit
Rapid; high-throughput screening of drugs and novel ligands.
Development of structure-activity relationship (SAR) models to predict Aromatase inhibition liability of novel compounds.
Prediction of adverse drug-drug interaction potential and bioavailability for compounds metabolized by Aromatase.
Sample Manual Insert of MBS846915. Click to request current manual
NCBI/Uniprot data below describe general gene information for CYP19A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Related Accession #
Molecular Weight
58,412 Da
NCBI Official Full Name
aromatase
NCBI Official Synonym Full Names
cytochrome P450, family 19, subfamily a, polypeptide 1
NCBI Official Symbol
Cyp19a1  [Similar Products]
NCBI Official Synonym Symbols
Cyp19; Cyp19a; p450arom; Aromatase
  [Similar Products]
NCBI Protein Information
aromatase
UniProt Protein Name
Aromatase
UniProt Synonym Protein Names
CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase
UniProt Gene Name
Cyp19a1  [Similar Products]
UniProt Synonym Gene Names
Arom; Cyp19  [Similar Products]
NCBI Summary for CYP19A
catalyzes end-step estrogen formation from androgens and aromatization of testosterone to estradiol [RGD, Feb 2006]
UniProt Comments for CYP19A
CYP19A1: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.14.14; Lipid Metabolism - androgen and estrogen; Oxidoreductase

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: cell soma; cytoplasm; cytosol; dendritic spine; endoplasmic reticulum; nerve terminal; synapse; synaptic vesicle; terminal button

Molecular Function: heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Biological Process: adrenal gland development; androgen catabolic process; androgen metabolic process; bile acid metabolic process; biphenyl metabolic process; C21-steroid hormone metabolic process; dibenzo-p-dioxin metabolic process; estrogen biosynthetic process; female genitalia development; female gonad development; granulocyte differentiation; hippocampus development; hypothalamus development; luteinization; male gonad development; mammary gland development; melatonin metabolic process; negative regulation of bone resorption; negative regulation of chronic inflammatory response; phthalate metabolic process; regulation of synapse structure and activity; response to cesium; response to drug; response to estradiol stimulus; response to estrogen stimulus; response to herbicide; response to ionizing radiation; response to metal ion; response to morphine; response to organic cyclic substance; response to testosterone stimulus; uterus development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with CYP19A assay kit
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