NP_000887.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,739 Da
NCBI Official Full Name
docosahexaenoic acid omega-hydroxylase CYP4F3 isoform a
NCBI Official Synonym Full Names
cytochrome P450 family 4 subfamily F member 3
NCBI Protein Information
docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Protein Name
Docosahexaenoic acid omega-hydroxylase CYP4F3
UniProt Synonym Protein Names
20-hydroxyeicosatetraenoic acid synthase
UniProt Synonym Gene Names
NCBI Summary for CYP4F3
This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for CYP4F3
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B4, a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.
Research Articles on CYP4F3
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Pathways associated with CYP4F3 recombinant protein
Diseases associated with CYP4F3 recombinant protein
Organs/Tissues associated with CYP4F3 recombinant protein
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