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Dab2 recombinant protein :: Disabled homolog 2 (Dab2) Recombinant Protein

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Catalog # MBS958698
Unit / Price
  0.05 mg (E-Coli)  /  $1,200 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,335 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,585 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,620 +2 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,655 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,695 +2 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,790 +2 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,875 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,380 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,415 +3 FREE 8GB USB
  1 mg (E-Coli)  /  $2,525 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,830 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,160 +3 FREE 8GB USB
Dab2 recombinant protein
Product Name

Disabled homolog 2 (Dab2), Recombinant Protein

Popular Item
Also Known As

Recombinant Mouse Disabled homolog 2 (Dab2)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-766aa, Full Length of Mature Protein
Sequence Length
548
Sequence
SNEVETSTTN GQPDQQAAPK APSKKEKKKG SEKTDEYLLA RFKGDGVKYK AKLIGIDDVP DARGDKMSQD SMMKLKGMAA AGRSQGQHKQ RIWVNISLSG IKIIDEKTGV IEHEHPVNKI SFIARDVTDN RAFGYVCGGE GQHQFFAIKT GQQAEPLVVD LKDLFQVIYN VKKKEEDKKK VEEANKAEEN GSEALMTLDD QANKLKLGVD QMDLFGDMST PPDLNSPTES KDILLVDLNS EIDTNQNSLR ENPFLTNGVT SCSLPRPKPQ ASFLPENAFS ANLNFFPTPN PDPFRDDPFA QPDQSAPSSF DSLTSPDQKK ASLSSSSTPQ SKGPLNGDTD YFGQQFDQLS NRTGKPEAQG GPWPYPSSQT QQAVRTQNGV SEREQNGFHI KSSPNPFVGS PPKGLSVPNG VKQDLESSVQ SSAHDSIAII PPPQSTKPGR GRRTAKSSAN DLLASDIFAS EPPGQMSPTG QPAVPQSNFL DLFKGNAPAP VGPLVGLGTV PVTPPQAGPW TPVVYSPSTT VVPGAIISGQ PPSFRQPLVF GTTPAVQVWN QSPSFATPAS PPPPTVWCPT TSVAPNAWSS TSPLGNPFQS NNIFPPPTMS TQSSPQPMMS SVLATPPQPP PRNGPLKDIP SDAFTGLDPL GDKEVKEVKE MFKDFQLRQP PLVPSRKGET PPSGTSSAFS SYFNNKVGIP QEHVDHDDFD ANQLLNKINE PPKPAPRQGV LLGTKSADNS LENPFSKGFS SSNPSVVSQP ASSDPHRSPF GNPFA
3D Structure
ModBase 3D Structure for P98078
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Dab2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Dab2 recombinant protein
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).
NCBI/Uniprot data below describe general gene information for Dab2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,822 Da
NCBI Official Full Name
disabled homolog 2 isoform b
NCBI Official Synonym Full Names
disabled 2, mitogen-responsive phosphoprotein
NCBI Official Symbol
NCBI Official Synonym Symbols
p96; Doc2; Doc-2; AA960054; AI957090; D15Wsu122e; 5730435J12Rik; D630005B22Rik
  [Similar Products]
NCBI Protein Information
disabled homolog 2
UniProt Protein Name
Disabled homolog 2
UniProt Synonym Protein Names
Adaptor molecule disabled-2; Differentially expressed in ovarian carcinoma 2; DOC-2; Mitogen-responsive phosphoprotein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Doc2; DOC-2  [Similar Products]
UniProt Comments for Dab2
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Isoform p96 is involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Isoform p67 is not involved in LDL receptor endocytosis. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. Isoform p67 may be involved in transcriptional regulation. May act as a tumor suppressor.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withDab2 recombinant protein
 Reference Product  PubMed Publications
 Lrp1 recombinant protein  >1 publications with Dab2 and Lrp1
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