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anti-CDH3 antibody :: Rabbit P-Cadherin Antibody

Scan QR to view Datasheet Catalog #    MBS8501498
Testing Data
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

P-Cadherin (CDH3), Antibody

 Also Known As   

P-Cadherin Antibody

 Product Synonym Names    DHP; HJMD; PCAD; CDH3
 Product Gene Name   

anti-CDH3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601553
 3D Structure    ModBase 3D Structure for P22223
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Immunogen    Recombinant protein of human CDH3
 Species    Rabbit
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 Preparation and Storage    Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-CDH3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CDH3 antibody

   Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congentialhypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]
 Product Categories/Family for anti-CDH3 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CDH3 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CDH3 antibody    WB: 1:500 - 1:2000, IHC: 1:50- 1:200
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 Testing Data of anti-CDH3 antibody    Western blot analysis of extracts of A431 cellslines, using CDH3 antibody.
anti-CDH3 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CDH3. It may not necessarily be applicable to this product.
 NCBI GI #    14589891
 NCBI GeneID    1001
 NCBI Accession #    NP_001784.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001793.4 [Other Products]
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 UniProt Primary Accession #    P22223 [Other Products]
 UniProt Secondary Accession #    Q05DI6; B2R6F4 [Other Products]
 UniProt Related Accession #    P22223 [Other Products]
 Molecular Weight    91kDa [Similar Products]
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 NCBI Official Full Name    cadherin-3 preproprotein
 NCBI Official Synonym Full Names    cadherin 3, type 1, P-cadherin (placental)
 NCBI Official Symbol    CDH3 [Similar Products]
 NCBI Official Synonym Symbols   
CDHP; HJMD; PCAD
[Similar Products]
 NCBI Protein Information    cadherin-3; calcium-dependent adhesion protein, placental
 UniProt Protein Name    Cadherin-3
 UniProt Synonym Protein Names   
Placental cadherin; P-cadherin
 UniProt Gene Name    CDH3 [Similar Products]
 UniProt Synonym Gene Names    CDHP; P-cadherin [Similar Products]
 UniProt Entry Name    CADH3_HUMAN
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 NCBI Summary for CDH3    This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDH3    CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cell-cell adherens junction; cytoplasm; integral to membrane; plasma membrane

Molecular Function: calcium ion binding

Biological Process: response to drug; positive regulation of insulin-like growth factor receptor signaling pathway; intercellular junction assembly and maintenance; wound healing; positive regulation of melanin biosynthetic process; Wnt receptor signaling pathway through beta-catenin; retinal homeostasis; hair cycle process; negative regulation of transforming growth factor-beta2 production; cell-cell adhesion; negative regulation of catagen; positive regulation of monophenol monooxygenase activity; visual perception; keratinization; homophilic cell adhesion; cell adhesion

Disease: Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome; Hypotrichosis, Congenital, With Juvenile Macular Dystrophy
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 Research Articles on CDH3    1. The X-dimer plays a key role in the specific cell-cell adhesion mediated by human P-cadherin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDH3 antibodyPathways associated with anti-CDH3 antibody
 Reference Product  PubMed Publications
 CDH1 antibody  >21 publications with CDH3 and CDH1
 CTNNB1 antibody  >4 publications with CDH3 and CTNNB1
 Products by Pathway  Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
Diseases associated with anti-CDH3 antibodyOrgans/Tissues associated with anti-CDH3 antibody
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >28 publications with CDH3 and Skin Diseases
 Gastrointestinal Diseases Antibodies  >15 publications with CDH3 and Gastrointestinal Diseases
 Breast Neoplasms Antibodies  >13 publications with CDH3 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with CDH3 and Neoplasms, Experimental
 Adenoma Antibodies  >4 publications with CDH3 and Adenoma
 Ectodermal dysplasia, ectrodactyly, and macular dystrophy Antibodies  >4 publications with CDH3 and Ectodermal dysplasia, ectrodactyly, and macular dystrophy
 Inflammation Antibodies  >3 publications with CDH3 and Inflammation
 Lung Neoplasms Antibodies  >3 publications with CDH3 and Lung Neoplasms
 Lung Diseases Antibodies  >3 publications with CDH3 and Lung Diseases
 Kidney Diseases Antibodies  >2 publications with CDH3 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >7 publications with CDH3 and Skin
 Intestine Antibodies  >5 publications with CDH3 and Intestine
 Lung Antibodies  >5 publications with CDH3 and Lung
 Blood Antibodies  >5 publications with CDH3 and Blood
 Stomach Antibodies  >4 publications with CDH3 and Stomach
 Liver Antibodies  >4 publications with CDH3 and Liver
 Eye Antibodies  >4 publications with CDH3 and Eye
 Embryonic Tissue Antibodies  >4 publications with CDH3 and Embryonic Tissue
 Thyroid Antibodies  >3 publications with CDH3 and Thyroid
 Placenta Antibodies  >2 publications with CDH3 and Placenta
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