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anti-TFAM antibody :: Rabbit anti-Human TFAM Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7004771
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TFAM, Polyclonal Antibody

★Popular Item★
 Also Known As   

TFAM Antibody

 Product Synonym Names    Transcription factor A; mitochondrial; mtTFA; Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2; TFAM; TCF6; TCF6L2
 Product Gene Name   

anti-TFAM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600438
 3D Structure    ModBase 3D Structure for Q00059
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Transcription factor A, mitochondrial protrin (43-246AA)
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30963 / sc-30962 / sc-19050 / sc-28200
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TFAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TFAM antibody

   Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
 Applications Tested/Suitable for anti-TFAM antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TFAM antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-TFAM antibody    Western blot
All lanes: TFAM antibody at 8ug/ml
Lane 1:Jurkat whole cell lysate
Lane 2:MCF-7 whole cell lysate
Lane 3:A431 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 30,26 kDa
Observed band size: 25 kDa

anti-TFAM antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TFAM antibody    Immunohistochemistry of paraffin-embedded human testis using MBS7004771 at dilution 1:100
anti-TFAM antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TFAM. It may not necessarily be applicable to this product.
 NCBI GI #    399498566
 NCBI GeneID    7019
 NCBI Accession #    NP_001257711.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001270782.1 [Other Products]
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 UniProt Primary Accession #    Q00059 [Other Products]
 UniProt Secondary Accession #    Q5U0C6; A8MRB2; A9QXC6; B5BU05 [Other Products]
 UniProt Related Accession #    Q00059 [Other Products]
 Molecular Weight    25,466 Da
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 NCBI Official Full Name    transcription factor A, mitochondrial isoform 2
 NCBI Official Synonym Full Names    transcription factor A, mitochondrial
 NCBI Official Symbol    TFAM [Similar Products]
 NCBI Official Synonym Symbols   
TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3
[Similar Products]
 NCBI Protein Information    transcription factor A, mitochondrial
 UniProt Protein Name    Transcription factor A, mitochondrial
 UniProt Synonym Protein Names   
Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2
 Protein Family    Transcription factor
 UniProt Gene Name    TFAM [Similar Products]
 UniProt Synonym Gene Names    TCF6; TCF6L2; mtTFA; MtTF1; TCF-6 [Similar Products]
 UniProt Entry Name    TFAM_HUMAN
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 NCBI Summary for TFAM    This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
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 UniProt Comments for TFAM    TFAM: regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M.

Protein type: DNA-binding; Transcription regulation

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: cytosol; mitochondrial matrix; mitochondrion; nucleus

Molecular Function: chromatin binding; DNA bending activity; heat shock protein binding; protein binding; transcription factor activity

Biological Process: DNA-dependent DNA replication; gene expression; mitochondrial respiratory chain complex assembly; mitochondrion organization and biogenesis; organelle organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase I promoter; transcription from mitochondrial promoter; transcription from RNA polymerase II promoter; transcription initiation from mitochondrial promoter
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 Research Articles on TFAM    1. TFAM overexpression suppressed mitoROS and their upregulation in rat cardiomyocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFAM antibodyPathways associated with anti-TFAM antibody
 Reference Product  PubMed Publications
 PPARGC1A antibody  >144 publications with TFAM and PPARGC1A
 NRF1 antibody  >133 publications with TFAM and NRF1
 SIRT1 antibody  >53 publications with TFAM and SIRT1
 TFB2M antibody  >44 publications with TFAM and TFB2M
 TFB1M antibody  >26 publications with TFAM and TFB1M
 POLRMT antibody  >22 publications with TFAM and POLRMT
 GABPA antibody  >12 publications with TFAM and GABPA
 PPARGC1B antibody  >7 publications with TFAM and PPARGC1B
 PPRC1 antibody  >2 publications with TFAM and PPRC1
 TP53 antibody  >1 publications with TFAM and TP53
 Products by Pathway  Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Mitochondrial Gene Expression Pathway antibodies  Mitochondrial Gene Expression Pathway Diagram
 Mitochondrial Biogenesis Pathway antibodies  Mitochondrial Biogenesis Pathway Diagram
 Mitochondrial Transcription Initiation Pathway antibodies  Mitochondrial Transcription Initiation Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 Transcription From Mitochondrial Promoters Pathway antibodies  Transcription From Mitochondrial Promoters Pathway Diagram
Diseases associated with anti-TFAM antibodyOrgans/Tissues associated with anti-TFAM antibody
 Disease Name  Pubmed Publications
 Mitochondrial Diseases Antibodies  >127 publications with TFAM and Mitochondrial Diseases
 Disease Models, Animal Antibodies  >64 publications with TFAM and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >60 publications with TFAM and Cardiovascular Diseases
 Insulin Resistance Antibodies  >47 publications with TFAM and Insulin Resistance
 Inflammation Antibodies  >43 publications with TFAM and Inflammation
 Heart Diseases Antibodies  >40 publications with TFAM and Heart Diseases
 Necrosis Antibodies  >30 publications with TFAM and Necrosis
 Liver Diseases Antibodies  >21 publications with TFAM and Liver Diseases
 Fatty Liver Antibodies  >20 publications with TFAM and Fatty Liver
 Hyperglycemia Antibodies  >18 publications with TFAM and Hyperglycemia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >239 publications with TFAM and Muscle
 Heart Antibodies  >101 publications with TFAM and Heart
 Brain Antibodies  >97 publications with TFAM and Brain
 Liver Antibodies  >91 publications with TFAM and Liver
 Blood Antibodies  >89 publications with TFAM and Blood
 Connective Tissue Antibodies  >34 publications with TFAM and Connective Tissue
 Vascular Antibodies  >29 publications with TFAM and Vascular
 Lung Antibodies  >23 publications with TFAM and Lung
 Kidney Antibodies  >19 publications with TFAM and Kidney
 Eye Antibodies  >15 publications with TFAM and Eye
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