EAW48578
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,496 Da
NCBI Official Full Name
chromosome 6 open reading frame 166
NCBI Official Synonym Full Names
akirin 2
NCBI Protein Information
akirin-2; fourteen-three-three beta interactant 1
UniProt Protein Name
Akirin-2
UniProt Synonym Gene Names
UniProt Entry Name
AKIR2_HUMAN
UniProt Comments for AKIRIN2
AKIRIN2: Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1. Belongs to the akirin family.
Protein type: Transcription regulation; Cell cycle regulation
Chromosomal Location of Human Ortholog: 6q15
Cellular Component: transcriptional repressor complex; nucleus
Molecular Function: enzyme binding
Biological Process: embryonic development; transcription, DNA-dependent; positive regulation of cell proliferation; innate immune response; positive regulation of interleukin-6 production; positive regulation of transcription from RNA polymerase II promoter; response to lipopolysaccharide; negative regulation of transcription from RNA polymerase II promoter
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Diseases associated with AKIRIN2 blocking peptide
Organs/Tissues associated with AKIRIN2 blocking peptide
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