NP_005992
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted: 50 kDa
Observed: 45 kDa
NCBI Official Full Name
tubulin alpha-3C/D chain
NCBI Official Synonym Full Names
tubulin, alpha 3c
NCBI Protein Information
tubulin alpha-3C/D chain; alpha-tubulin 2; tubulin, alpha 2; alpha-tubulin 3C/D; tubulin alpha-2 chain
UniProt Protein Name
Tubulin alpha-3C/D chain
UniProt Synonym Protein Names
Alpha-tubulin 2; Alpha-tubulin 3C/D; Tubulin alpha-2 chain
UniProt Synonym Gene Names
UniProt Entry Name
TBA3C_HUMAN
NCBI Summary for TUBA3C
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for TUBA3C
TUBA3C/D: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Testis specific. Belongs to the tubulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q11
Cellular Component: microtubule; cytoplasm; nucleus
Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton
Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; microtubule-based process
Research Articles on TUBA3C
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Pathways associated with anti-TUBA3C antibody
Diseases associated with anti-TUBA3C antibody
Organs/Tissues associated with anti-TUBA3C antibody
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