NP_001101.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 10
NCBI Official Synonym Symbols
RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717 [Similar Products]
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 10
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 10
UniProt Synonym Protein Names
CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD_antigen: CD156c
UniProt Synonym Gene Names
NCBI Summary for ADAM10
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]
UniProt Comments for ADAM10
ADAM10: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
Protein type: Cell adhesion; Cell surface; EC 3.4.24.81; Membrane protein, integral; Motility/polarity/chemotaxis; Protease; Vesicle
Chromosomal Location of Human Ortholog: 15q21.3
Cellular Component: cell surface; cytoplasm; endoplasmic reticulum lumen; extracellular exosome; focal adhesion; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; integral component of membrane; membrane; nucleus; plasma membrane; postsynaptic density
Molecular Function: endopeptidase activity; integrin binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein homodimerization activity; protein kinase binding; receptor binding; SH3 domain binding
Biological Process: cell-cell signaling; cellular protein metabolic process; constitutive protein ectodomain proteolysis; extracellular matrix disassembly; in utero embryonic development; integrin-mediated signaling pathway; membrane protein ectodomain proteolysis; monocyte activation; negative regulation of cell adhesion; neutrophil degranulation; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of T cell chemotaxis; post-translational protein modification; protein amino acid phosphorylation; protein processing; response to tumor necrosis factor
Disease: Alzheimer Disease 18; Reticulate Acropigmentation Of Kitamura
Research Articles on ADAM10
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Products associated with anti-ADAM10 antibody
Pathways associated with anti-ADAM10 antibody
Diseases associated with anti-ADAM10 antibody
Organs/Tissues associated with anti-ADAM10 antibody
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