NP_001020130.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,552 Da
NCBI Official Full Name
actin-related protein 2/3 complex subunit 4 isoform b
NCBI Official Synonym Full Names
actin related protein 2/3 complex subunit 4
NCBI Protein Information
actin-related protein 2/3 complex subunit 4
UniProt Protein Name
Actin-related protein 2/3 complex subunit 4
UniProt Synonym Protein Names
Arp2/3 complex 20 kDa subunit; p20-ARC
UniProt Synonym Gene Names
NCBI Summary for ARPC4
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
UniProt Comments for ARPC4
ARPC4: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Belongs to the ARPC4 family.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: Arp2/3 protein complex; cell projection; cytosol
Molecular Function: actin filament binding; enzyme binding; protein binding; protein binding, bridging; structural constituent of cytoskeleton
Biological Process: actin filament polymerization; actin nucleation; ephrin receptor signaling pathway
Research Articles on ARPC4
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Products associated with anti-ARPC4 antibody
Pathways associated with anti-ARPC4 antibody
Diseases associated with anti-ARPC4 antibody
Organs/Tissues associated with anti-ARPC4 antibody
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